Evidence map›Paper›PMID 38741082›Full record

SynthesisBMC cancer2024

Prognostic value of the advanced lung cancer inflammation index in patients with gastric cancer after radical gastrectomy: a propensity-score matching cohort study and meta-analysis.

Huayang Pang, Lingyan Dai, Lihui Chen, Xiufeng Chen, Zhixiong Chen, Shouru Zhang, Hao Sun

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huayang PangDepartment of Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, 400030, China.
Lingyan DaiDepartment of Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, 400030, China.
Lihui ChenDepartment of Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, 400030, China.
Xiufeng ChenDepartment of Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, 400030, China.
Zhixiong ChenDepartment of Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, 400030, China.
Shouru ZhangDepartment of Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, 400030, China. zsrhjp@126.com.
Hao SunDepartment of Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, 400030, China. sunhao68@sina.com.

Funding

Research Institutions Performance Incentive Guidance Special Fund cstc2022jxjl0234the Joint project of Chongqing Health Commission and Science and Technology Bureau No. 2021MSXM309
6 · The paper itself

Abstract

backgroundInsufficient evidence existed about the prognostic role of the advanced lung cancer inflammation index (ALI) for gastric cancer patients who underwent curative resection. The aim of this study was to identify the predictive ability of ALI for survival after curative gastrectomy.

methodsWe retrospectively analyzed 328 gastric cancer patients who received curative gastrectomy from the database of Chongqing University Cancer Hospital, and investigated the prognostic role of the preoperative ALI compared with clinicopathological variables and other serum biomarkers, such as preoperative neutrophil-to-lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and Lymphocyte-monocyte ratio (LMR). To minimize intergroup differences, propensity score matching (PSM) analysis was employed. Additionally, we performed a meta-analysis of four cohort studies published up to October 2023 following the PRISMA guidelines.

resultsIn the overall cohort, patients in the low ALI group had a significantly worse overall survival compared to those in the high ALI group (P < 0.0001). Subgroup analysis identified that ALI maintained its prognostic significance across different subgroups. In addition, ROC analysis showed that ALI had a higher AUC value for 3-year overall survival compared to NLR, PLR, and LMR (0.576 vs. 0.573 vs. 0.557 vs. 0.557). Multivariate analysis indicated that ALI, other than other serum biomarkers, was an independent risk factor for decreased overall survival in GC patients following curative surgery (HR = 1.449; 95%CI: 1.028-2.045; P = 0.034). Consistently, PSM analysis supported all of these findings. The meta-analysis including 4 studies evaluating 2542 patients, confirmed the association between the low ALI and poor survival outcomes.

conclusionThe preoperative ALI was an independent prognostic factor for survival in gastric cancer patients who underwent curative gastrectomy.

Indexed as

GastrectomyInflammationStomach NeoplasmsHumansLymphocytesNeutrophilsPrognosisPropensity ScoreRetrospective StudiesAdvanced lung cancer inflammation indexGastric cancerMeta-analysisPrognostic valuePropensity-score matched analysis

Identifiers

PMID38741082
PMCPMC11089784

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.