Evidence map›Paper›PMID 38741069›Full record

ArticleBMC cancer2024

PTEN and P-4E-BP1 might be associated with postoperative recurrence of rectal cancer patients undergoing concurrent radiochemotherapy.

Heng Zhang, Xiaofan Li, Wanjun Sun, Haoren Qin, Haipeng Li, Hao Yan, Huaqing Wang, Xipeng Zhang, Shiwu Zhang, Hui Wang

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In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Heng ZhangDepartment of Oncology, Tianjin Union Medical Center, Nankai University, No.190 Jieyuan Road, Hongqiao District, Tianjin, 300121, P. R. China.
Xiaofan LiDepartment of Oncology, People's Hospital of Rongcheng, Shandong, Rongcheng, P. R. China.
Wanjun SunDepartment of Oncology, Tianjin Union Medical Center, Nankai University, No.190 Jieyuan Road, Hongqiao District, Tianjin, 300121, P. R. China.
Haoren QinDepartment of Oncology, Tianjin Union Medical Center, Nankai University, No.190 Jieyuan Road, Hongqiao District, Tianjin, 300121, P. R. China.
Haipeng LiDepartment of Oncology, Tianjin Union Medical Center, Nankai University, No.190 Jieyuan Road, Hongqiao District, Tianjin, 300121, P. R. China.
Hao YanDepartment of Oncology, Tianjin Union Medical Center, Nankai University, No.190 Jieyuan Road, Hongqiao District, Tianjin, 300121, P. R. China.
Huaqing WangDepartment of Oncology, Tianjin Union Medical Center, Nankai University, No.190 Jieyuan Road, Hongqiao District, Tianjin, 300121, P. R. China.
Xipeng ZhangDepartment of Colorectal Surgery, Tianjin Union Medical Center, Nankai University, Tianjin, P. R. China.
Shiwu ZhangDepartment of Pathology, Tianjin Union Medical Center, Nankai University, Tianjin, P. R. China.
Hui WangDepartment of Oncology, Tianjin Union Medical Center, Nankai University, No.190 Jieyuan Road, Hongqiao District, Tianjin, 300121, P. R. China. ezxwanghui@sina.com.

Funding

Foundation of Tianjin Union Medical Center 2022ZLXK07National Natural Science Foundation of China 81972847Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-053B
6 · The paper itself

Abstract

backgroundLocal recurrence after surgery and radiochemotherapy seriously affects the prognosis of locally advanced rectal cancer (LARC) patients. Studies on molecular markers related to the radiochemotherapy sensitivity of cancers have been widely carried out, which might provide valued information for clinicians to carry out individual treatment.

aimTo find potential biomarkers of tumors for predicting postoperative recurrence.

methodsIn this study, LARC patients undergoing surgery and concurrent radiochemotherapy were enrolled. We focused on clinicopathological factors and PTEN, SIRT1, p-4E-BP1, and pS6 protein expression assessed by immunohistochemistry in 73 rectal cancer patients with local recurrence and 76 patients without local recurrence.

resultsThe expression of PTEN was higher, while the expression of p-4E-BP1 was lower in patients without local recurrence than in patients with local recurrence. Moreover, TNM stage, lymphatic vessel invasion (LVI), PTEN and p-4E-BP1 might be independent risk factors for local recurrence after LARC surgery combined with concurrent radiochemotherapy.

conclusionsThis study suggests that PTEN and p-4E-BP1 might be potential biomarkers for prognostic prediction and therapeutic targets for LARC.

Indexed as

Adaptor Proteins, Signal TransducingBiomarkers, TumorCell Cycle ProteinsChemoradiotherapyNeoplasm Recurrence, LocalPTEN PhosphohydrolaseRectal NeoplasmsAdultAgedFemaleHumansMaleMiddle AgedNeoplasm StagingPhosphoproteinsPrognosisAdaptor Proteins, Signal TransducingBiomarkers, TumorCell Cycle ProteinsEIF4EBP1 protein, humanPhosphoproteinsPTEN PhosphohydrolasePTEN protein, human4E-BP1Concurrent radiochemotherapyLocal recurrencePTENRectal cancer

Identifiers

PMID38741069
PMCPMC11089754

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