ArticleNature neuroscience2024
Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency.
Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Sequence termination cues drive automated habit-like strategy via dopamine-mediated processes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Methamphetamine potentiates the use of outcome-specific associations via a hypothalamic-dopamine circuit.Neuron · 2026Article
- Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum.Neuron · 2025Article
- Estrogen modulates reward prediction errors and reinforcement learning.Nature neuroscience · 2025Article
- Article
- Superior Colliculus Projections Drive Dopamine Neuron Activity and Movement But Not Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- VTA dopamine neuron activity produces spatially organized value representations.bioRxiv : the preprint server for biology · 2025Article
- Deliberating on the role of dopamine.Trends in cognitive sciences · 2025Article
- Stimulus-Dependent Dopamine Dynamics from Locus Coeruleus Axons.bioRxiv : the preprint server for biology · 2025Article
- Superior colliculus projections drive dopamine neuron activity and movement but not value.bioRxiv : the preprint server for biology · 2025Article
- Sequence termination cues drive habits via dopamine-mediated credit assignment.bioRxiv : the preprint server for biology · 2025Article
- Modulation of Dopamine Neurons Alters Behavior and Event Encoding in the Nucleus Accumbens during Pavlovian Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Multi-Frequency Interpolation X-talk Removal Algorithm: Enabling Combinations of Concurrent Optogenetics and Lock-in Amplification Fiber Photometry via Removal of Optogenetic Stimulation Crosstalk.ACS chemical neuroscience · 2025Article
- The curious case of dopaminergic prediction errors and learning associative information beyond value.Nature reviews. Neuroscience · 2025Review
- Complementary roles of serotonin and dopamine in model-based learning.Current opinion in behavioral sciences · 2025Article
- How Dopamine Enables Learning from Aversion.Current opinion in behavioral sciences · 2025Article
- Article
- Sensory cues potentiate VTA dopamine mediated reinforcement.bioRxiv : the preprint server for biology · 2023Article
- Theoretical Considerations for Optimizing the Use of Optogenetics with Complex Behavior.Current protocols · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Dopamine neurons in the ventral tegmental area support intracranial self-stimulation (ICSS), yet the cognitive representations underlying this phenomenon remain unclear. Here, 20-Hz stimulation of dopamine neurons, which approximates a physiologically relevant prediction error, was not sufficient to support ICSS beyond a continuously reinforced schedule and did not endow cues with a general or specific value. However, 50-Hz stimulation of dopamine neurons was sufficient to drive robust ICSS and was represented as a specific reward to motivate behavior. The frequency dependence of this effect is due to the rate (not the number) of action potentials produced by dopamine neurons, which differently modulates dopamine release downstream.
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