Evidence map›Paper›PMID 38741016›Full record

ArticleNature genetics2024

Harnessing clonal gametes in hybrid crops to engineer polyploid genomes.

Yazhong Wang, Roven Rommel Fuentes, Willem M J van Rengs, Sieglinde Effgen, Mohd Waznul Adly Mohd Zaidan, Rainer Franzen, Tamara Susanto, Joiselle Blanche Fernandes, Raphael Mercier, Charles J Underwood

Abstract read
In one paragraph

Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Breeding better crops: lessons from the homologous recombination pathway.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Review
  4. Unraveling the complexity of the oilseed rape genome: from sequencing to gene discovery for trait improvement.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Review
  5. Article
  6. Review
  7. Understanding and harnessing unreduced gametes for crop improvement.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. The DNA mismatch repair protein Msh4 is essential for meiosis of male but not for female in zebrafish.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
    Article
  12. Article
  13. Article
  14. Engineering Synthetic Apomixis in Hybrid Rice.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yazhong WangDepartment of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany.ORCID http://orcid.org/0000-0001-8150-7230
Roven Rommel FuentesDepartment of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany.ORCID http://orcid.org/0009-0002-8512-619X
Willem M J van RengsDepartment of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany.
Sieglinde EffgenDepartment of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany.
Mohd Waznul Adly Mohd ZaidanDepartment of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany.
Rainer FranzenCentral Microscopy (CeMic), Max Planck Institute for Plant Breeding Research, Cologne, Germany.
Tamara SusantoDepartment of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany.ORCID http://orcid.org/0000-0002-4785-1166
Joiselle Blanche FernandesDepartment of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany.ORCID http://orcid.org/0000-0003-2540-2439
Raphael MercierDepartment of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany.ORCID http://orcid.org/0000-0001-6508-6608
Charles J UnderwoodDepartment of Chromosome Biology, Max Planck Institute for Plant Breeding Research, Cologne, Germany. cunderwood@mpipz.mpg.de.ORCID http://orcid.org/0000-0001-5730-6279

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) UN 442
6 · The paper itself

Abstract

Heterosis boosts crop yield; however, harnessing additional progressive heterosis in polyploids is challenging for breeders. We bioengineered a 'mitosis instead of meiosis' (MiMe) system that generates unreduced, clonal gametes in three hybrid tomato genotypes and used it to establish polyploid genome design. Through the hybridization of MiMe hybrids, we generated '4-haplotype' plants that encompassed the complete genetics of their four inbred grandparents, providing a blueprint for exploiting polyploidy in crops.

Indexed as

Crops, AgriculturalGenome, PlantHybridization, GeneticHybrid VigorPlant BreedingPolyploidySolanum lycopersicumGenetic EngineeringGerm CellsGerm Cells, PlantMeiosisMitosis

Identifiers

PMID38741016
PMCPMC11176054

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.