Evidence map›Paper›PMID 38740996›Full record

ArticleNature medicine2024

Screening and diagnosis of cardiovascular disease using artificial intelligence-enabled cardiac magnetic resonance imaging.

Yan-Ran Joyce Wang, Kai Yang, Yi Wen, Pengcheng Wang, Yuepeng Hu, Yongfan Lai, Yufeng Wang, Kankan Zhao, Siyi Tang, Angela Zhang and 18 more

Abstract read
In one paragraph

Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Yan-Ran Joyce Wang *School of Medicine, Stanford University, Stanford, CA, USA. wangyanran100@gmail.com.ORCID 0000-0002-1369-3892
Kai Yang *Department of Magnetic Resonance Imaging, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yi WenChanghong AI Research (CHAIR), Sichuan Changhong Electronics Holding Group, Mianyang, China.
Pengcheng WangDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Yuepeng HuDepartment of Electrical and Computer Engineering, Duke University, Durham, NC, USA.ORCID 0009-0005-9053-5782
Yongfan LaiSchool of Engineering, University of Science and Technology of China, Hefei, China.
Yufeng WangDepartment of Computer Science, Stony Brook University, New York, NY, USA.ORCID 0000-0003-0640-8536
Kankan ZhaoPaul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. kk.zhao@siat.ac.cn.
Siyi TangSchool of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7504-5885
Angela ZhangSchool of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0906-6770
Huayi ZhanChanghong AI Research (CHAIR), Sichuan Changhong Electronics Holding Group, Mianyang, China.ORCID 0000-0002-6375-6724
Minjie LuDepartment of Magnetic Resonance Imaging, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xiuyu ChenDepartment of Magnetic Resonance Imaging, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Shujuan YangDepartment of Magnetic Resonance Imaging, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhixiang DongDepartment of Magnetic Resonance Imaging, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yining WangPeking Union Medical College Hospital, Beijing, China.
Hui LiuGuangdong Provincial People's Hospital, Guangzhou, China.
Lei ZhaoBeijing Anzhen Hospital, Beijing, China.
Lu HuangTongji Hospital, Wuhan, China.
Yunling LiThe Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Lianming WuRenji Hospital, Shanghai, China.
Zixian ChenThe First Hospital of Lanzhou University, Lanzhou, China.
Yi LuoThe First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Dongbo LiuChanghong AI Research (CHAIR), Sichuan Changhong Electronics Holding Group, Mianyang, China.
Pengbo ZhaoDepartment of Electrical and Computer Engineering, Northwestern University, Evanston, IL, USA.
Keldon LinMayo Clinic Alix School of Medicine, Phoenix, AZ, USA.
Joseph C WuSchool of Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6068-8041
Shihua ZhaoDepartment of Magnetic Resonance Imaging, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. cjrzhaoshihua2009@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac magnetic resonance imaging (CMR) is the gold standard for cardiac function assessment and plays a crucial role in diagnosing cardiovascular disease (CVD). However, its widespread application has been limited by the heavy resource burden of CMR interpretation. Here, to address this challenge, we developed and validated computerized CMR interpretation for screening and diagnosis of 11 types of CVD in 9,719 patients. We propose a two-stage paradigm consisting of noninvasive cine-based CVD screening followed by cine and late gadolinium enhancement-based diagnosis. The screening and diagnostic models achieved high performance (area under the curve of 0.988 ± 0.3% and 0.991 ± 0.0%, respectively) in both internal and external datasets. Furthermore, the diagnostic model outperformed cardiologists in diagnosing pulmonary arterial hypertension, demonstrating the ability of artificial intelligence-enabled CMR to detect previously unidentified CMR features. This proof-of-concept study holds the potential to substantially advance the efficiency and scalability of CMR interpretation, thereby improving CVD screening and diagnosis.

Indexed as

Artificial IntelligenceCardiovascular DiseasesAdultAgedFemaleHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleMass ScreeningMiddle Aged

Identifiers

PMID38740996
PMCPMC11108784

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.