Evidence map›Paper›PMID 38740931›Full record

ArticleNature microbiology2024

Dynamics of measles immunity from birth and following vaccination.

Wei Wang, Megan O'Driscoll, Qianli Wang, Sihong Zhao, Henrik Salje, Hongjie Yu

Abstract read
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In one paragraph

Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Seroprevalence against measles, Austria, stratified by birth years 1922 to 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  9. What's going on with measles?Journal of virology · 2024
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei WangSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.ORCID http://orcid.org/0000-0003-4056-3732
Megan O'DriscollDepartment of Genetics, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7972-5703
Qianli WangShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
Sihong ZhaoSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
Henrik SaljeDepartment of Genetics, University of Cambridge, Cambridge, UK. hs743@cam.ac.uk.ORCID http://orcid.org/0000-0003-3626-4254
Hongjie YuSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China. yhj@fudan.edu.cn.ORCID http://orcid.org/0000-0002-6335-5648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Measles remains a major threat to human health despite widespread vaccination. While we know that maternal antibodies can impair vaccine-induced immunity, the relative contributions of pre-existing immunity levels, maternal and infant characteristics on vaccine responses remain unclear, hampering evidence-based vaccination policy development. Here we combine serological data from 1,505 individuals (aged 0-12 years) in a mother-infant cohort and in a child cohort with empirical models to reconstruct antibody trajectories from birth. We show that while highly heterogeneous across a population, measles antibody evolution is strongly predictive from birth at the individual level, including following vaccination. Further, we find that caesarean section births were linked with 2.56 (95% confidence interval: 1.06-6.37) increased odds of primary vaccine failure, highlighting the long-term immunological consequences of birth route. Finally, we use our new understanding of antibody evolution to critically assess the population-level consequences of different vaccination schedules, the results of which will allow country-level evaluations of vaccine policy.

Indexed as

Antibodies, ViralMeaslesMeasles VaccineVaccinationAdultChildChild, PreschoolCohort StudiesFemaleHumansImmunity, Maternally-AcquiredInfantInfant, NewbornMaleMeasles virusPregnancyAntibodies, ViralMeasles Vaccine

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.