SynthesisScientific reports2024
Global seroprevalence of scrub typhus: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Burden of scrub typhus in north-eastern region of India: A systematic review and meta-regression analysis.The Indian journal of medical research · 2026Pooled it
- Movement Disorders in Scrub Typhus: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Pooled it
- Scrub Typhus Meningoencephalitis With Concurrent Brucellosis in Rural Nepal: Diagnostic Challenges With Negative PCR in a Low-Resource Setting.Clinical case reports · 2026Article
- Tsutsugamushi Disease in a Non-endemic Season and Region: Suspected Indoor Exposure via Pet-associated Vector Entry.Internal medicine (Tokyo, Japan) · 2026Article
- Scrub Typhus Presenting with Isolated Xerostomia.The American journal of tropical medicine and hygiene · 2026Article
- Mapping Scrub Typhus Across Multiple Hosts in India.EcoHealth · 2026Review
- Non-linear effects and lag patterns of eco-environmental factors on scrub typhus: a spatiotemporal analysis in Yunnan, China, 2015-2022.Parasites & vectors · 2026Article
- High infant mortality, eschar absence, and universal CNS involvement in scrub typhus-associated HLH: a case series and narrative synthesis of 91 pediatric cases.Tropical medicine and health · 2026Article
- Orientia tsutsugamushi targets lamin A using Ank effectors and alters chromatin to inhibit NF-κB.Communications biology · 2026Article
- A Compact Closed Genome ofPathogens (Basel, Switzerland) · 2026Article
- Concurrent splenic and renal infarction in scrub typhus: expanding the vasculitic spectrum.BMC infectious diseases · 2026Article
- Clinical and laboratory indicators of severe scrub typhus in adults: Insights from a retrospective study in a teaching hospital in South India.Journal of family medicine and primary care · 2026Article
- Advancing the diagnosis of scrub typhus with targeted next-generation sequencing.Frontiers in microbiology · 2026Article
- Scrub typhus triggers hemophagocytic lymphohistiocytosis in children: metagenomic next-generation sequencing enables rapid diagnosis.Frontiers in public health · 2026Article
- A Clinico-Epidemiological Study of Scrub Typhus Cases in a Tertiary Care Center of a Non-endemic Area.Cureus · 2025Article
- Clinical and laboratory factors associated with scrub typhus and hemorrhagic fever with renal syndrome in Southwestern Korea: A cross-sectional study.PLoS neglected tropical diseases · 2025Article
- Genetic Characterization of Orientia tsutsugamushi, Bhutan, 2015.Emerging infectious diseases · 2025Article
- Pneumonia due to scrub typhus infection: a case report.BMC pulmonary medicine · 2025Article
- Epidemiological characteristics and influencing factors of scrub typhus in Jiangxi Province.Parasites & vectors · 2025Article
- The Association Between Environmental Factors and Scrub Typhus: A Review.Tropical medicine and infectious disease · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scrub typhus, a neglected disease, is a significant health concern in the Tsutsugamushi triangle of the Asia-Pacific and has raised global concerns due to recent cases occurring outside this region. To estimate the global prevalence of scrub typhus, we conducted a systematic review and meta-analysis. We conducted a systematic search of PubMed, Scopus, and Embase databases for observational studies on scrub typhus. Using a random-effects model, we combined the prevalence estimates with inverse-variance weights while also evaluating heterogeneity and publication bias. Among 3551 reports screened, we identified 181 studies with 1,48,251 samples for inclusion in our synthesis. The overall pooled seroprevalence (95% confidence intervals) of scrub typhus infections was 24.93% (23.27-26.60). Gender-wise pooled prevalence was estimated to be 50.23% (47.05-53.40) for males and 48.84% (45.87-51.80) for females. Eschar prevalence was observed to be 30.34% (22.54-38.15) among the positive cases. One-fourth of all the samples tested positive for scrub typhus and eschar was present in one-third of these total positive cases, encompassing regions beyond the Tsutsugamushi triangle. This estimation underlines the importance of this neglected disease as a public health problem. Strengthening surveillance and implementing disease control measures are needed in the affected regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.