ArticleScientific reports2024
Revealing the complexity of meniscus microvasculature through 3D visualization and analysis.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Stepwise micro-CT analysis of sample processing effects on the 3D morphology of human intervertebral discs.Osteoarthritis and cartilage open · 2026Article
- Characterization of calcifications in posterior horn of human meniscus using micro-computed tomography.Osteoarthritis and cartilage open · 2026Article
- Standardized MRI nomenclature for knee meniscal lesions: SSR consensus panel report.Skeletal radiology · 2026Review
- All-inside meniscal repair using polyether ether ketone versus all-suture anchors: No difference in failure rates at three-follow-up in a retrospective cohort of 2253 patients.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Comprehensive zonal assessment of meniscal degeneration using quantitative UTE MRI.Osteoarthritis and cartilage · 2026Article
- Isolated meniscal repair, medial meniscus repair and older age increase failure risk after all-inside meniscal repair: A cohort study of 2264 patients.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Integrated mapping of human meniscus and cartilage eQTLs reveals shared and distinct osteoarthritis genetic drivers.medRxiv : the preprint server for health sciences · 2026Article
- Double Posterior Cruciate Ligament Sign.Reports (MDPI) · 2026Article
- The ageing meniscus: Pathophysiology, epidemiology and management.Journal of experimental orthopaedics · 2026Article
- Zonally patterned demineralized bone matrix-meniscus ECM composite scaffold directing region-specific fibrochondrogenic and angiogenic responses.Regenerative biomaterials · 2026Article
- Integrated strategies in meniscus tissue engineering: from biomaterials to stem cell-driven regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Bionic scaffolds with integrated structural components based on low-temperature deposition manufacturing 3D printing technology for the treatment of meniscus defects.Bioengineering & translational medicine · 2025Article
- High failure rate in meniscal repair when preceding anterior cruciate ligament reconstruction: An analysis of two-stage surgery for concomitant ACL injury and traumatic meniscus tear.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Vascularization Characteristics of the Different Meniscal Layers: Three-Dimensional Assessment With Micro-CT.Orthopaedic journal of sports medicine · 2025Article
- Structure-property relationships in fibrous meniscal tissue through image-based augmentation.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Biomechanics of medial meniscus tears in the context of pain: a finite element analysis.Frontiers in bioengineering and biotechnology · 2025Article
- Spatial and temporal evaluation of iodine uptake and radiodensity in meniscus tissue using contrast-enhanced micro-CT.Heliyon · 2024Article
- Imaging Techniques for Meniscal Vasculature: A Systematic Review of Clinical and Translational Applications.Journal of clinical medicine · 2024Review
- Understanding the Structure-Function Relationship through 3D Imaging and Biomechanical Analysis: A Novel Methodological Approach Applied to Anterior Cruciate Ligaments.Biomimetics (Basel, Switzerland) · 2024Article
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Authors and funding
8 authors.
Funding
Abstract
Three-dimensional information is essential for a proper understanding of the healing potential of the menisci and their overall role in the knee joint. However, to date, the study of meniscal vascularity has relied primarily on two-dimensional imaging techniques. Here we present a method to elucidate the intricate 3D meniscal vascular network, revealing its spatial arrangement, connectivity and density. A polymerizing contrast agent was injected into the femoral artery of human cadaver legs, and the meniscal microvasculature was examined using micro-computed tomography at different levels of detail and resolution. The 3D vascular network was quantitatively assessed in a zone-base analysis using parameters such as diameter, length, tortuosity, and branching patterns. The results of this study revealed distinct vascular patterns within the meniscus, with the highest vascular volume found in the outer perimeniscal zone. Variations in vascular parameters were found between the different circumferential and radial meniscal zones. Moreover, through state-of-the-art 3D visualization using micro-CT, this study highlighted the importance of spatial resolution in accurately characterizing the vascular network. These findings, both from this study and from future research using this technique, improve our understanding of microvascular distribution, which may lead to improved therapeutic strategies.
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