ArticleNature communications2024
The basal forebrain to lateral habenula circuitry mediates social behavioral maladaptation.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Sustained hyperactivity of parasubthalamic nucleus by PACAP signaling mediates stress-induced anxiety.Molecular psychiatry · 2026Article
- Distinct projections of PVN oxytocin neurons regulate the divergent defensive behaviors in response to social threat.Science advances · 2026Article
- The lateral habenula as a master regulator of innate and learned social behaviors.Psychopharmacology · 2026Review
- Glutamatergic projection neurons in the basal forebrain underlie learned olfactory associational valence assignments.Nature communications · 2026Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- A cell-type-specific circuit of somatostatin neurons in the habenula encodes antidepressant action in male mice.Nature communications · 2025Article
- Characteristics of the amygdala and its subregions in premenstrual syndrome/premenstrual dysphoric disorder patients.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Dynamic changes of media prefrontal cortex astrocytic activity in response to negative stimuli in male mice.Neurobiology of stress · 2024Article
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Authors and funding
9 authors.
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Abstract
Elucidating the neural basis of fear allows for more effective treatments for maladaptive fear often observed in psychiatric disorders. Although the basal forebrain (BF) has an essential role in fear learning, its function in fear expression and the underlying neuronal and circuit substrates are much less understood. Here we report that BF glutamatergic neurons are robustly activated by social stimulus following social fear conditioning in male mice. And cell-type-specific inhibition of those excitatory neurons largely reduces social fear expression. At the circuit level, BF glutamatergic neurons make functional contacts with the lateral habenula (LHb) neurons and these connections are potentiated in conditioned mice. Moreover, optogenetic inhibition of BF-LHb glutamatergic pathway significantly reduces social fear responses. These data unravel an important function of the BF in fear expression via its glutamatergic projection onto the LHb, and suggest that selective targeting BF-LHb excitatory circuitry could alleviate maladaptive fear in relevant disorders.
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