Evidence map›Paper›PMID 38740702›Full record

Observational studyJournal of cancer survivorship : research and practice2025

Health-related conditions among long-term cancer survivors diagnosed in adolescence and young adulthood (AYA): results of the SURVAYA study.

Silvie H M Janssen, Carla Vlooswijk, Rhodé M Bijlsma, Suzanne E J Kaal, Jan Martijn Kerst, Jacqueline M Tromp, Monique E M M Bos, Tom van der Hulle, Roy I Lalisang, Janine Nuver and 3 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05379387 (Health-related Quality of Life and Late Effects Among SURVivors of Cancer in Adolescence and Young Adulthood), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05379387 completednot on this map

Health-related Quality of Life and Late Effects Among SURVivors of Cancer in Adolescence and Young Adulthood: The SURVAYA Study

TypeobservationalSponsorThe Netherlands Cancer InstituteRan2019 to 2021Enrolled4,000ConditionsQuality of Life, Late Effect, Survivorship, Lifestyle
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Silvie H M JanssenDepartment of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands.ORCID 0000-0003-1406-1739
Carla VlooswijkResearch and Development, Netherlands Comprehensive Cancer Organization, 3511 DT, Utrecht, The Netherlands.ORCID 0000-0001-8885-6302
Rhodé M BijlsmaDepartment of Medical Oncology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.ORCID 0000-0003-0980-6652
Suzanne E J KaalDepartment of Medical Oncology, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.ORCID 0000-0002-8063-0074
Jan Martijn KerstDepartment of Medical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, 1066 CX, Amsterdam, the Netherlands.
Jacqueline M TrompDepartment of Medical Oncology, Amsterdam University Medical Centers, 1105 AZ, Amsterdam, The Netherlands.
Monique E M M BosDepartment of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 GD, Rotterdam, The Netherlands.ORCID 0000-0002-9415-6342
Tom van der HulleDepartment of Medical Oncology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.ORCID 0000-0002-2296-1828
Roy I LalisangDivision of Medical Oncology, Department of Internal Medicine, Maastricht UMC+ Comprehensive Cancer Center, GROW-School of Oncology and Reproduction, Maastricht University Medical Center+, 6229 HX, Maastricht, The Netherlands.ORCID 0000-0002-9752-0947
Janine NuverDepartment of Medical Oncology, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands.ORCID 0000-0001-7966-5301
Mathilde C M KouwenhovenDepartment of Neurology, Cancer Center Amsterdam, Amsterdam UMC, Amsterdam University Medical Centers, Location VUmc, 1081 HV, Amsterdam, The Netherlands.ORCID 0000-0001-5252-4365
Winette T A van der GraafDepartment of Medical Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, 1066 CX, Amsterdam, the Netherlands.ORCID 0000-0001-7549-3338
Olga HussonDepartment of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, 1066 CX, Amsterdam, the Netherlands. o.husson@erasmusmc.nl.ORCID 0000-0002-1387-8686

Funding

KWF Kankerbestrijding #11788 COMPRAYA studyNederlandse Organisatie voor Wetenschappelijk Onderzoek VIDI grant 198.007
6 · The paper itself

Abstract

backgroundWith 5-year survival rates > 85%, gaining insight into the long-term and late health-related conditions of cancer survivors diagnosed in adolescence and young adulthood is of utmost importance to improve their quantity and quality of survival. This study examined the prevalence of and factors associated with, patient-reported health-related conditions and their latency times among long-term adolescent and young adult (AYA) cancer survivors.

methodsAYA cancer survivors (5-20 years after diagnosis) were identified by the population-based Netherlands Cancer Registry (NCR), and invited to participate in the SURVAYA questionnaire study. Participants reported the prevalence and date of diagnosis of health-related conditions. Clinical data were retrieved from the NCR.

resultsThree thousand seven hundred seventy-six AYA cancer survivors (response rate 33.4%) were included for analyses. More than half of the AYAs (58.5%) experienced health-related conditions after their cancer diagnosis, of whom 51.4% were diagnosed with two or more conditions. Participants reported conditions related to vision (15.0%), digestive system (15.0%), endocrine system (14.1%), cardiovascular system (11.7%), respiratory system (11.3%), urinary tract system (10.9%), depression (8.6%), hearing (7.4%), arthrosis (6.9%), secondary malignancy (6.4%), speech-, taste and smell (4.5%), and rheumatoid arthritis (2.1%). Time since diagnosis, tumor type, age at diagnosis, and educational level were most frequently associated with a health-related condition.

conclusionsA significant proportion of long-term AYA cancer survivors report having one or more health-related conditions. IMPLICATIONS FOR CANCER SURVIVORS: Future research should focus on better understanding the underlying mechanisms of, and risk factors for, these health-related conditions to support the development and implementation of risk-stratified survivorship care for AYA cancer survivors to further improve their outcomes. CLINICAL TRIALS REGISTRATION: NCT05379387.

Indexed as

Cancer SurvivorsNeoplasmsAdolescentAdultFemaleHumansMaleNetherlandsPrevalenceQuality of LifeRegistriesSurveys and QuestionnairesYoung AdultAdolescents and young adultsAYAsCancerHealth-related conditionsPopulation-based dataSurvivorship

Identifiers

PMID38740702
PMCPMC12546281

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.