ArticleNatural products and bioprospecting2024
Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core.
Xin-Ting Hu, Qing-Yan Cheng, Yan-Ping Chen, Kun Li, Cai-Xian Yan, Dashan Li, Li-Dong Shao
Abstract read
In one paragraphArticle in Natural products and bioprospecting, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Xin-Ting Hu *Yunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Qing-Yan Cheng *Yunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Yan-Ping ChenYunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Kun LiYunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Cai-Xian YanYunnan Precious Metals Laboratory, Kunming Institute of Precious Metals, Kunming, 650106, China.
Dashan LiYunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Li-Dong ShaoYunnan Key Laboratory of Southern Medicinal Utilization, School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming, 650500, China. shaolidong@ynucm.edu.cn.ORCID http://orcid.org/0000-0003-4799-6784 Funding
Bioactive Ethnopharmacol Molecules Chemical Conversion and Application Innovation Team of Department of Education of Yunnan Province 2022National Natural Science Foundation of China 22267024National Natural Science Foundation of China 82260683Scientific and Technological Project of Yunnan Precious Metals Laboratory YPML-2023050217Scientific and Technological Project of Yunnan Precious Metals Laboratory YPML-2023050265Start-up Fund of Yunnan University of Chinese Medicine 2019YZG03Top Young Talent of Ten Thousand Talents Program of Yunnan Province D. L.Top Young Talent of Ten Thousand Talents Program of Yunnan Province L.-D. S.Yunnan Science and Technology Talent and Platform Program 202105AG070012
6 · The paper itselfAbstract
A catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successfully utilized to prepare various 1,3-dioxanes 7 in 14-88% yields. Take advantage of the synthetic intermediate 7h, the key B/C rings in brazilin core could be constructed by the sequential of Friedel-Crafts/Ullmann-Ma rather than Ullmann-Ma/Friedel-Crafts reactions.
Indexed as
1,3-DiarylpropeneBrazilinCatalytic Prins reactionHydroxymethylation/hydroxylation
Identifiers
PMID38740677
PMCPMC11091033
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