Evidence map›Paper›PMID 38740597›Full record

SynthesisParasitology research2024

The prevalence of Pfk13 polymorphism in malaria patients treated with artemisinin-based therapy: a systematic review and meta-analysis.

Dang The Hung, Linh Tran, Dao Ngoc Hien Tam, Ghada Elshafei, Nguyen The Ky Cuong, Nam Xuan Ha, Sarah Abd Elaziz Khader, Loc Le Quang, Hosam Waleed Shaikhkhalil, Abdallfatah Abdallfatah and 3 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Parasitology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dang The Hung *School of Biomedical Engineering & Imaging Sciences, Faculty of life Sciences & Medicine, Kings College London, London, WC2R 2LS, UK.ORCID http://orcid.org/0000-0001-6109-5208
Linh Tran *Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, 700000, Vietnam.ORCID http://orcid.org/0000-0001-8667-082X
Dao Ngoc Hien Tam *Online Research Club, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0003-0162-2373
Ghada ElshafeiOnline Research Club, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0001-6626-8972
Nguyen The Ky CuongOnline Research Club, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0002-8465-6896
Nam Xuan HaOnline Research Club, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0003-2202-2916
Sarah Abd Elaziz KhaderOnline Research Club, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0002-4397-3852
Loc Le QuangOnline Research Club, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0001-6363-9862
Hosam Waleed ShaikhkhalilOnline Research Club, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0003-1384-3886
Abdallfatah AbdallfatahOnline Research Club, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0002-5670-2234
Jeza M Abdul AzizBiomedical Sciences, Komar University of Science and Technology, Sulaymaniyah, Iraq.ORCID http://orcid.org/0000-0002-1522-1880
Kenji HirayamaSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan.ORCID http://orcid.org/0000-0001-9467-1777
Nguyen Tien HuySchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, 852-8523, Japan. tienhuy@nagasaki-u.ac.jp.ORCID http://orcid.org/0000-0002-9543-9440

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artemisinin (ART) combination therapy is the main treatment for malaria. Pfk13 mutations (or K13 mutations, Kelch 13) are associated with ART resistance. This study aims to conduct a systematic review and meta-analysis of the prevalence of K13 mutations with ART resistance in malaria-endemic countries. An electronic search of studies in 2018 and a manual search in 2020 were performed to identify relevant studies. The risk of bias was assessed using the National Institutes of Health (NIH) quality assessment tool for observational cohort and cross-sectional studies. Data analysis was performed using R 4.1.0. Heterogeneity was estimated using the statistic I

Indexed as

AntimalarialsArtemisininsPolymorphism, GeneticAsia, SoutheasternDrug ResistanceHumansMalariaMalaria, FalciparumMutationPlasmodium falciparumPrevalenceProtozoan ProteinsAntimalarialsartemisininArtemisininsProtozoan ProteinsArtemisininK13 mutationsKelch 13MalariaResistance

Identifiers

PMID38740597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.