Evidence map›Paper›PMID 38740379›Full record

ArticleACS applied materials & interfaces2024

Nanohydroxyapatite Coating Attenuates Fibrotic and Immune Responses to Promote Keratoprosthesis Biointegration in Advanced Ocular Surface Disorders.

Arun J Thirunavukarasu, Fernando Morales-Wong, Nuur Shahinda Humaira Binte Halim, Evelina Han, Siew Kwan Koh, Lei Zhou, Viridiana Kocaba, Subramanian Venkatraman, Jodhbir S Mehta, Andri K Riau

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Article in ACS applied materials & interfaces, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arun J ThirunavukarasuTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore.
Fernando Morales-WongTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore.
Nuur Shahinda Humaira Binte HalimTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore.
Evelina HanTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore.
Siew Kwan KohOcular Proteomics Group, Singapore Eye Research Institute, Singapore 169856, Singapore.
Lei ZhouDepartment of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Hong Kong.
Viridiana KocabaTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore.
Subramanian VenkatramanDepartment of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore.
Jodhbir S MehtaTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore.
Andri K RiauTissue Engineering and Cell Therapy Group, Singapore Eye Research Institute, Singapore 169856, Singapore.ORCID 0000-0002-5105-0484

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Keratoprosthesis (KPro) implantation is frequently the only recourse for patients with severe corneal disease. However, problems arise due to inadequate biointegration of the KPro, particularly the PMMA optical cylinder, such as tissue detachment, tissue melting, or eye-threatening infection in the interface. Here, using the AuroKPro as a model prosthesis, a surface functionalization approach─coating the optical cylinder with nanohydroxyapatite (nHAp)─was trialed in rabbit eyes with and without a proceeding chemical injury. In chemically injured eyes, which simulated total limbal epithelial stem cell deficiency, clear benefits were conferred by the coating. The total modified Hackett-McDonald score and area of tissue apposition differences 12 weeks after implantation were 5.0 and 22.5%, respectively. Mechanical push-in tests revealed that 31.8% greater work was required to detach the tissues. These differences were less marked in uninjured eyes, which showed total score and tissue apposition differences of 2.5 and 11.5%, respectively, and a work difference of 23.5%. The improved biointegration could be contributed by the attenuated expression of fibronectin (

Indexed as

DurapatiteAnimalsCoated Materials, BiocompatibleCorneaCorneal DiseasesFibrosisHumansProstheses and ImplantsRabbitsCoated Materials, BiocompatibleDurapatitebiointegrationcorneahydroxyapatiteimmune responsekeratoprosthesissurface modification

Identifiers

PMID38740379
PMCPMC11129699

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.