Evidence map›Paper›PMID 38740369›Full record

ReviewSeminars in respiratory and critical care medicine2024

Novel Therapeutic Approaches in Connective Tissue Disease-Associated Interstitial Lung Disease.

Erica Mulcaire-Jones, Janelle Vu Pugashetti, Justin M Oldham, Dinesh Khanna

Abstract readReview
In one paragraph

Review in Seminars in respiratory and critical care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Erica Mulcaire-JonesDivision of Rheumatology, Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Janelle Vu PugashettiDivision of Pulmonary and Critical Care Medicine, Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Justin M OldhamDivision of Pulmonary and Critical Care Medicine, Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Dinesh KhannaDivision of Rheumatology, Internal Medicine, University of Michigan, Ann Arbor, Michigan.

Funding

Proteomic Profiling of Idiopathic Pulmonary Fibrosis Progression TrajectoryR01HL169166 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin M Oldham · 2023 to 2026
$2.7M
Prognostic Biomarker Development in Progressive Fibrosing Interstitial Lung DiseaseR01HL166290 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin M Oldham · 2024 to 2026
$2.2M
A Multi-Dimensional Signature to Predict Treatment Failure in Patients with Connective Tissue Disease-Associated Interstitial Lung DiseaseK23HL171871 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Janelle Vu Pugashetti · 2025 to 2026
$392k
NHLBI NIH HHS K23 HL171871NHLBI NIH HHS R01 HL166290NHLBI NIH HHS R01 HL169166
6 · The paper itself

Abstract

Connective tissue diseases (CTD) comprise a group of autoimmune diseases that can affect multiple organs in the body including the lungs. The most common form of pulmonary involvement is interstitial lung disease (ILD). CTD-associated ILD (CTD-ILD) can take one of several courses including nonprogressive, chronically progressive, or rapidly progressive. Chronically and rapidly progressive patterns are associated with increased mortality. Limited randomized controlled trial data are available for treatment of CTD-ILD, with most data coming from systemic sclerosis-related ILD. The current first-line treatment for all CTD-ILD is immunosuppression with consideration of antifibrotics, stem cell transplant, and lung transplant in progressive disease. In this article, we review data for ILD treatment options in systemic sclerosis, rheumatoid arthritis, myositis, and primary Sjögren's syndrome-related ILDs.

Indexed as

Connective Tissue DiseasesImmunosuppressive AgentsLung Diseases, InterstitialArthritis, RheumatoidDisease ProgressionHumansLung TransplantationMyositisRandomized Controlled Trials as TopicScleroderma, SystemicSjogren's SyndromeStem Cell TransplantationImmunosuppressive Agents

Identifiers

PMID38740369
PMCPMC11875204

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.