Observational studyThe Annals of thoracic surgery2024
Impact of Extracorporeal Membrane Oxygenation Bridging Duration on Lung Transplant Outcomes.
Observational study in The Annals of thoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Extracorporeal membrane oxygenation as a bridge to lung transplant in the composite lung allocation score era: A single-center experience.JTCVS open · 2026Article
- Donor-size-normalized tidal volume and early peak airway pressure-derived pressure burden after lung transplantation: an exploratory single-center cohort study.Frontiers in medicine · 2026Article
- Impact of pre-transplant veno-venous extracorporeal membrane oxygenation on post-lung transplant infections.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Outcomes of venovenous-extracorporeal membrane oxygenation bridging in lung transplant recipients with panel reactive antibody positivity.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Duration of extracorporeal membrane oxygenation support and survival outcomes: a retrospective analysis for lung transplant recipients with idiopathic pulmonary fibrosis.Journal of thoracic disease · 2025Article
- Article
- Bridging to orthotopic heart transplant: Reducing the risk of intra-operative blood loss.JHLT open · 2025Article
- Postoperative conditions of rehabilitative interest in lung transplantation: a systematic review.Journal of Yeungnam medical science · 2024Article
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11 authors.
Funding
Abstract
backgroundWe sought to characterize the association between venovenous extracorporeal membrane oxygenation (VV-ECMO) bridging duration and outcomes in patients listed for lung transplantation.
methodsA retrospective observational study was conducted using the Organ Procurement and Transplantation Network (OPTN) database to identify adults (aged ≥18 years) who were listed for lung transplantation between 2016 and 2020 and were bridged with VV-ECMO. Patients were then stratified into groups, determined by risk inflection points, depending on the amount of time spent on pretransplant ECMO: group 1 (≤5 days), group 2 (6-10 days), group 3 (11-20 days), and group 4 (>20 days). Waiting list survival between groups was analyzed using Fine-Gray competing risk models. Posttransplant survival was compared using Cox regression.
resultsOf 566 eligible VV-ECMO bridge-to-lung-transplant patients (median age, 54 years, 49% men), 174 (31%), 124 (22%), 130 (23%), and 138 (24%) were categorized as groups 1, 2, 3, and 4, respectively. Overall, median duration of VV-ECMO was 10 days (interquartile range, 1-211 days), and 178 patients (31%) died on the waiting list. In the Fine-Gray model, compared with group 1, patients bridged with longer ECMO durations in group 2 (subdistribution hazard ratio [SHR], 2.95; 95% CI, 1.63-5.35), group 3 (SHR, 3.96; 95% CI, 2.36-6.63), and group 4 (SHR, 4.33; 95% CI, 2.59-7.22, all P < .001) were more likely to die on the waiting list. Of 388 patients receiving a transplant, pretransplant ECMO duration was not associated with 1-year survival in Cox regression.
conclusionsProlonged duration of ECMO bridging was associated with worse waiting list mortality but did not impact survival after lung transplant. Prioritization of very early transplantation may improve waiting list outcomes in this population.
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