Evidence map›Paper›PMID 38740050›Full record

ArticleJournal of sleep research2024

Respiration-triggered olfactory stimulation reduces obstructive sleep apnea severity: A prospective pilot study.

Ofer Perl, Lilach Kemer, Amit Green, Nissim Arish, Yael Corcos, Anat Arzi, Yaron Dagan

Abstract read
In one paragraph

Article in Journal of sleep research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ofer PerlDepartment of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-3560-4344
Lilach KemerThe Sleep and Fatigue Institute, Assuta Medical Center, Tel Aviv, Israel.
Amit GreenThe Sleep and Fatigue Institute, Assuta Medical Center, Tel Aviv, Israel.ORCID 0000-0002-5668-2712
Nissim ArishPulmonary Institute, Sha'are Zedek Medical Center, Jerusalem, Israel.
Yael CorcosAppscent Medical, Ra'anana, Israel.
Anat ArziDepartment of Medical Neurobiology, Institute for Medical Research Israel Canada, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
Yaron DaganThe Sleep and Fatigue Institute, Assuta Medical Center, Tel Aviv, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive sleep apnea is a prevalent sleep-disordered breathing condition characterized by repetitive reduction in breathing during sleep. The current care standard for obstructive sleep apnea is continuous positive air pressure devices, often suffering from low tolerance due to limited adherence. Capitalizing on the unique neurocircuitry of olfactory perception and its retained function during sleep, we conducted a pilot study to test transient, respiration-based olfactory stimulation as a treatment for obstructive sleep apnea markers. Thirty-two patients with obstructive sleep apnea (apnea-hypopnea index ≥ 15 events per hr) underwent two polysomnography sessions, "Odour" and "Control", in random order. In "Odour" nights, patients were presented with transient respiratory-based olfactory stimulation delivered via a computer-controlled commercial olfactometer (Scentific). The olfactometer, equipped with a wireless monitoring, analysed respiratory patterns and presented odour upon detection of respiratory events. No odours were presented in "Control" nights. Following exclusions, 17 patients entered the analysis (four women, 47.4 (10.5) years, body mass index: 29.4 (6.3) kg m

Indexed as

PolysomnographyRespirationSleep Apnea, ObstructiveAdultFemaleHumansMaleMiddle AgedOdorantsPilot ProjectsProspective StudiesSeverity of Illness IndexSmellapnea predictionbreathing disordersobstructive sleep apneaodourolfactionpersonalized medicinesleep

Identifiers

PMID38740050
PMCPMC11597002

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.