ArticleProceedings of the National Academy of Sciences of the United States of America2024
The modern human aryl hydrocarbon receptor is more active when ancestralized by genome editing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The aryl hydrocarbon receptor, CIITA and HLA-II: who is watching the watchdog?Journal of experimental & clinical cancer research : CR · 2026Article
- The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- DCHS1 Modulates Forebrain Proportions in Modern Humans via a Glycosylation Change.bioRxiv : the preprint server for biology · 2025Article
- Harnessing aryl hydrocarbon receptor dynamics: Unveiling therapeutic pathways in esophageal squamous cell carcinoma.World journal of experimental medicine · 2024Article
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4 authors.
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Abstract
The aryl hydrocarbon receptor (AHR) is a transcription factor that has many functions in mammals. Its best known function is that it binds aromatic hydrocarbons and induces the expression of cytochrome P450 genes, which encode enzymes that metabolize aromatic hydrocarbons and other substrates. All present-day humans carry an amino acid substitution at position 381 in the AHR that occurred after the divergence of modern humans from Neandertals and Denisovans. Previous studies that have expressed the ancestral and modern versions of AHR from expression vectors have yielded conflicting results with regard to their activities. Here, we use genome editing to modify the endogenous
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