ArticlePLoS neglected tropical diseases2024
Evolution and genetic characterization of Seoul virus in wild rats Rattus norvegicus from an urban park in Lyon, France 2020-2022.
Article in PLoS neglected tropical diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Viral pathogens in urban rats: A one health systematic review of global surveillance evidence.One health (Amsterdam, Netherlands) · 2026Review
- Revisiting Animal Reservoirs of Hantavirus and Other Zoonotic Viruses Associated with Cruise Travel: Impact and Prevention.Animals : an open access journal from MDPI · 2026Review
- Hantavirus Emergence in a Changing World: Virology, Pathogenesis, Surveillance, and One Health Preparedness.Microorganisms · 2026Review
- Surveillance of Zoonotic Pathogens in Small Mammals Across Forests With Different Levels of Anthropization in Eastern France.Transboundary and emerging diseases · 2026Article
- Orthohantavirus seoulense as a cause of acute, dengue-negative febrile illness in southern Vietnam.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2025Article
- Detection of two zoonotic pathogens,One health (Amsterdam, Netherlands) · 2025Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundSeoul virus (SEOV) is an orthohantavirus primarily carried by rats. In humans, it may cause hemorrhagic fever with renal syndrome (HFRS). Its incidence is likely underestimated and given the expansion of urban areas, a better knowledge of SEOV circulation in rat populations is called for. Beyond the need to improve human case detection, we need to deepen our comprehension of the ecological, epidemiological, and evolutionary processes involved in the transmission of SEOV. METHODOLOGY / PRINCIPAL
findingsWe performed a comprehensive serological and molecular characterization of SEOV in Rattus norvegicus in a popular urban park within a large city (Lyon, France) to provide essential information to design surveillance strategies regarding SEOV. We sampled rats within the urban park of 'La Tête d'Or' in Lyon city from 2020 to 2022. We combined rat population genetics, immunofluorescence assays, SEOV high-throughput sequencing (S, M, and L segments), and phylogenetic analyses. We found low structuring of wild rat populations within Lyon city. Only one sampling site within the park (building created in 2021) showed high genetic differentiation and deserves further attention. We confirmed the circulation of SEOV in rats from the park with high seroprevalence (17.2%) and high genetic similarity with the strain previously described in 2011 in Lyon city. CONCLUSION/SIGNIFICANCE: This study confirms the continuous circulation of SEOV in a popular urban park where the risk for SEOV transmission to humans is present. Implementing a surveillance of this virus could provide an efficient early warning system and help prepare risk-based interventions. As we reveal high gene flow between rat populations from the park and the rest of the city, we advocate for SEOV surveillance to be conducted at the scale of the entire city.
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