ArticleThe Journal of clinical endocrinology and metabolism2025
Estimation of Glucose Absorption, Insulin Sensitivity, and Glucose Effectiveness From the Oral Glucose Tolerance Test.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Clinical significance of lncRNA EGFR-AS1 in gestational diabetes mellitus and its regulation of endothelial cell function.Irish journal of medical science · 2026Article
- Insulin Hypersecretion and Increased Ectopic Fat in South Asian American Adolescents and Young Adults Compared With White and African American Peers: The CHARISMA Study.Diabetes care · 2026Article
- Dynamic OGTT-Derived Indices Outperform Fasting HOMA-2 for Detecting Dysglycemia in Transfusion-Dependent β-Thalassemia.Mediterranean journal of hematology and infectious diseases · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
contextGlucose tolerance during an oral glucose tolerance test (OGTT) is affected by variations in glucose effectiveness (GE) and glucose absorption and thus affects minimal model calculations of insulin sensitivity (SI). The widely used OGTT SI by Dalla Man et al does not account for variances in GE and glucose absorption.
objectiveTo develop a novel model that concurrently assesses SI, GE, and glucose absorption.
methodsIn this cross-sectional study conducted at an academic medical center, 17 subjects without abnormalities on OGTT (controls) and 88 subjects with diabetes underwent a 75-gram 120-minute 6-timepoint OGTT. The SI from the Dalla Man model was validated with the novel model SI using Bland-Altman limits of agreement methodology. Comparisons of SI, GE, and gastrointestinal glucose half-life (GIGt1/2), a surrogate measure for glucose absorption, were made between subjects with diabetes and controls.
resultsIn controls and diabetes, the novel model SI was higher than the current OGTT model. The SI from both controls (ƿ=0.90, P < .001) and diabetes (ƿ=0.77, P < .001) has high agreement between models. GE was higher in diabetes (median: 0.021 1/min, interquartile range [IQR]: 0.020-0.022) compared to controls (median: 0.016 1/min, IQR: 0.015-0.017), P = .02. GIGt1/2 was shorter in diabetes (median: 48.404 min, IQR: 54.424-39.426) than in controls (median: 55.086 min, IQR: 61.368-48.502) without statistical difference.
conclusionOur novel model SI has a good correlation with SI from the widely used Dalla Man's model while concurrently calculating GE and GIGt1/2. Thus, besides estimating SI, our novel model can quantify differences in insulin-independent glucose disposal mechanisms important for diabetes pathophysiology.
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