Evidence map›Paper›PMID 38739435›Full record

ArticleJMIR research protocols2024

Evaluating the Feasibility, Acceptance, and Beneficial Effects of Online Occupational Therapy for Post-COVID-19 Condition: Protocol for a Randomized Controlled Trial (ErgoLoCo Study).

Christina Müllenmeister, Andrea Stoelting, Dominik Schröder, Tim Schmachtenberg, Simon Ritter, Iman El-Sayed, Sandra Steffens, Frank Klawonn, Sandra Klawitter, Stefanie Homann and 8 more

Abstract readClinical Trial Protocol
In one paragraph

Article in JMIR research protocols, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Observational
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Christina Müllenmeister *Department of General Practice, University Medical Center Goettingen, Goettingen, Germany.ORCID 0000-0002-5500-7416
Andrea Stoelting *Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-7084-9013
Dominik Schröder *Department of General Practice, University Medical Center Goettingen, Goettingen, Germany.ORCID 0000-0002-3564-4725
Tim SchmachtenbergDepartment of General Practice, University Medical Center Goettingen, Goettingen, Germany.ORCID 0000-0002-4232-5095
Simon RitterDepartment of Pediatric Pulmology, Allergology and Neoantology, Hannover Medical School, Hannover, Germany.ORCID 0009-0007-8041-5044
Iman El-SayedDepartment of General Practice, University Medical Center Goettingen, Goettingen, Germany.ORCID 0009-0008-2792-9510
Sandra SteffensDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-7478-3920
Frank KlawonnDepartment of Computer Science, Ostfalia University of Applied Sciences, Wolfenbuettel, Germany.ORCID 0000-0001-9613-182X
Sandra KlawitterDepartment of Computer Science, Ostfalia University of Applied Sciences, Wolfenbuettel, Germany.ORCID 0000-0003-2741-5989
Stefanie HomannDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.ORCID 0009-0008-1482-4648
Marie MikuteitDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-8546-0548
Christoph BergFOM University of Applied Sciences for Economics and Management, Hannover, Germany.ORCID 0009-0003-7180-4807
Georg BehrensDepartment of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-3111-621X
Eva HummersDepartment of General Practice, University Medical Center Goettingen, Goettingen, Germany.ORCID 0000-0003-2707-6067
Aisha CookTimmcook Occupational Therapy Center, Hannover, Germany.ORCID 0009-0000-4144-0975
Frank MüllerDepartment of General Practice, University Medical Center Goettingen, Goettingen, Germany.ORCID 0000-0002-9496-9423
Alexandra Dopfer-Jablonka *Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.ORCID 0000-0001-7129-100X
Christine Happle *Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-0096-3272

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPost-COVID-19 syndrome (PCS; also known as "long COVID") is a relatively novel disease comprising physical, psychological, and cognitive complaints persisting several weeks to months after acute infection with SARS-CoV-2. Approximately 10% of patients with COVID-19 are affected by long-term symptoms. However, effective treatment strategies are lacking. The ErgoLoCo (Occupational Therapy [Ergotherapie] for Long COVID) study was designed to develop and evaluate a novel occupational therapy (OT) concept of online delivery of therapy for long COVID.

objectiveThe primary study objective is to assess the feasibility of the online OT intervention in PCS. Secondary aims include the evaluation of online OT concerning cognitive problems, occupational performance, and social participation.

methodsThis randomized controlled interventional pilot study involves parallel mixed methods process analyses and a realist evaluation approach. A total of 80 clients with PCS aged at least 16 years will be recruited into two interventional groups. The control cohort (watch and wait) comprises 80 clients with long COVID. Treatment is provided through teletherapy (n=40) or delivery of prerecorded videos (n=40) using the same standardized OT concept twice weekly over 12 weeks. Analyses of quantitative questionnaires and qualitative interviews based on the theoretical framework of acceptability will be performed to assess feasibility. Focus group meetings will be used to assess how acceptable and helpful the intervention was to the participating occupational therapists. Standardized tests will be used to assess the initial efficacy of the intervention on neurocognitive performance; limitations in mobility, self-care, and everyday activities; pain; disabilities; quality of life (QoL); social participation; and anxiety and depression in PCS, and the possible effects of online OT on these complaints.

resultsThe German Ministry of Education and Research provided funding for this research in March 2022. Data collection took place from October 2022 to August 31, 2023. Data analysis will be completed by the end of April 2024. We anticipate publishing the results in the fall of 2024.

conclusionsDespite the enormous clinical need, effective and scalable treatment options for OT clients who have PCS remain scarce. The ErgoLoCo study will assess whether online-delivered OT is a feasible treatment approach in PCS. Furthermore, this study will assess the effect of the intervention on cognitive symptoms, QoL, and occupational performance and participation in everyday life. Particular emphasis will be placed on the experiences of clients and occupational therapists with digitally delivered OT. This study will pave the way for novel and effective treatment strategies in PCS.

trial registrationGerman Clinical Trial Registry DRKS00029990; https://drks.de/search/de/trial/DRKS00029990. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/50230.

Indexed as

COVID-19Feasibility StudiesOccupational TherapyAdultFemaleGermanyHumansMaleMiddle AgedPilot ProjectsRandomized Controlled Trials as TopicSARS-CoV-2Telemedicineacceptabilitycognitive deficitscontrolled trialsCOVID-19digital healthdigital interventioneffectivenessfeasibilityinternet basedlong Covidoccupational therapyonline therapyonline treatmentpandemicpost COVID-19 conditionprerecordedrandomized controlled trialRCTSARS-CoV-2video

Identifiers

PMID38739435
PMCPMC11130769

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.