ArticleAging cell2024
Association of sarcopenia with the long-term risk of atrial fibrillation: A prospective cohort study.
Article in Aging cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between sarcopenia and atrial fibrillation: a meta-analysis.Frontiers in medicine · 2026Pooled it
- Validity, reliability and clinical utility of the Glittre ADL test in patients with atrial fibrillation.Open heart · 2026Article
- Cardio-Kidney-Metabolic Phenotypes in Atrial Fibrillation.JACC. Asia · 2026Article
- Joint associations of grip strength, lipid levels, and lipid-related genetic risk with atrial fibrillation.Lipids in health and disease · 2026Article
- Neutrophil-to-Albumin Ratio Mediates the Association Between Life's Crucial 9 and Sarcopenia: A Cross-Sectional Study.Health science reports · 2026Article
- Exploratory phase angle assessment after atrial fibrillation ablation in overweight patients: a pilot study.BMC cardiovascular disorders · 2026Article
- Effect of sarcopenia on risk of atrial fibrillation: a systematic review and meta-analysis of observational studies.Frontiers in cardiovascular medicine · 2026Review
- Sarcopenia in atrial fibrillation: a prospective study.Turkish journal of medical sciences · 2026Article
- Sarcopenia in atrial fibrillation: a risk factor for adverse outcomes in a UK Biobank study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Sex- and Age-Stratified relative handgrip strength and risk of eight chronic diseases in Middle-Aged and older adults: evidence from a National aging cohort study in China.Aging clinical and experimental research · 2025Article
- Impact of sarcopenia on the clinical efficacy of delta large-channel endoscopic treatment of lumbar spinal stenosis in older adults: a retrospective cohort study.BMC musculoskeletal disorders · 2025Article
- Combined effect of skeletal muscle mass loss and elevated insulin resistance on heart failure risk in older adults: a community-based longitudinal cohort study.Cardiovascular diabetology · 2025Article
- Sarcopenia and Insulin Resistance Collective Effect on Atrial Fibrillation Risk: A Non-Diabetic Elderly Cohort Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Sarcopenia and Cardiogeriatrics: The Links Between Skeletal Muscle Decline and Cardiovascular Aging.Nutrients · 2025Review
- Association of sarcopenia with the long-term risk of atrial fibrillation: A prospective cohort study.Aging cell · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The relationship between sarcopenia and the long-term risk of atrial fibrillation (AF) remains unclear. This study recruited a large prospective Caucasian cohort from the UK Biobank. Participants were assessed at baseline with handgrip strength and muscle mass and were categorized into groups of non-sarcopenia, probable sarcopenia, and confirmed sarcopenia. Kaplan-Meier method and Cox proportional hazards model were used to explore the association between sarcopenia and the incidence of AF. The genetic predisposition of AF was assessed by polygenic risk score. Sensitivity analyses were performed to validate the results. A total of 384,433 participants with a median age of 58 years and 54.3% women were enrolled in this study. There were 24,007 cases of new-onset AF over a median follow-up of 12.56 years. The groups of non-sarcopenia, probable sarcopenia, and confirmed sarcopenia accounted for 22,290 (6.1%), 1665 (9.2%), and 52 (11.9%) cases, respectively. Compared with the non-sarcopenia group, participants with probable sarcopenia or confirmed sarcopenia had an 8% (95% CI, 1.03-1.14) or 61% (95% CI, 1.23-2.12) higher risk of AF incidence. The findings remained robust in multiple sensitivity analyses, such as subgroup analysis and further adjustment of genetic predisposition. Notably, the association between sarcopenia and a high AF risk was more pronounced in younger participants, women, and those with valvular heart disease. In conclusion, sarcopenia was associated with a high long-term risk of AF in Caucasians, supporting sarcopenia as a new independent risk factor of AF.
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