Evidence map›Paper›PMID 38739353›Full record

ArticleForensic toxicology2024

Can the cyanide metabolite, 2-aminothiazoline-4-carboxylic acid, be used for forensic verification of cyanide poisoning?

Abdullah H Alluhayb, Carter Severance, Tara Hendry-Hofer, Vikhyat S Bebarta, Brian A Logue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Forensic toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Abdullah H AlluhaybDepartment of Chemistry, Biochemistry and Physics, Avera Health and Science Center, South Dakota State University, 1055 Campanile Ave, Box 2202, Brookings, SD, 57007, USA.
Carter SeveranceDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Tara Hendry-HoferDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Vikhyat S BebartaDepartment of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Brian A LogueDepartment of Chemistry, Biochemistry and Physics, Avera Health and Science Center, South Dakota State University, 1055 Campanile Ave, Box 2202, Brookings, SD, 57007, USA. Brian.Logue@sdstate.edu.ORCID 0000-0002-2400-9339

Funding

Cyanalyzer A Medical Laboratory Device for the Rapid Diagnosis of Cyanide ExposureR44NS097066 · NINDS · SEACOAST SCIENCE, INC. · PI JACKSON, RANDY · 2016 to 2017
$2.9M
NINDS NIH HHS R44 NS097066NINDS NIH HHS R44NS97066-01A1
6 · The paper itself

Abstract

purposeForensic verification of cyanide (CN) poisoning by direct CN analysis in postmortem blood is challenging due to instability of CN in biological samples. CN metabolites, thiocyanate (SCN

methodsCN, SCN

resultsFollowing CN poisoning, the concentration of each CN biomarker increased well above the baseline. In postmortem swine, CN concentrations declined rapidly (t

conclusionWhile there are still questions to be answered, ATCA was the most adept forensic marker of CN poisoning (i.e., ATCA produced the longest half-life, the largest increase above baseline levels, and most stable background concentrations).

Indexed as

BiomarkersCyanidesAnimalsForensic ToxicologyModels, AnimalSpecimen HandlingSwineTemperatureThiazolesThiocyanates2-amino-delta(2)-thiazoline-4-carboxylic acidBiomarkersCyanidesThiazolesthiocyanateThiocyanates2-amino-2-thiazoline-4-carboxylic acidBiomarkers of cyanide exposureCyanide poisoningForensic analysisThiocyanate

Identifiers

PMID38739353
PMCPMC11269370

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.