Evidence map›Paper›PMID 38739285›Full record

ArticleMolecular biology reports2024

The ameliorative effect of vinpocetine against gentamicin-induced uterine-injury in rats involves the inflammasome/caspase-1/IL-1β pathway.

Ayman Geddawy, Mina Ezzat Attya, AbdelRahman Hegazy, Mostafa Kamal AbdElhaseeb, Michael Atef Fawzy, Medhat Atta, Fatma F Ali, Walaa Yehia Abdelzaher

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Ayman GeddawyDepartment of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
Mina Ezzat AttyaDepartment of Pathology, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
AbdelRahman HegazyDepartment of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
Mostafa Kamal AbdElhaseebDepartment of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
Michael Atef FawzyDepartment of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61511, Egypt.
Medhat AttaDepartment of Anatomy, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
Fatma F AliMedical Physiology Department, Faculty of Medicine, Minia University, Minia, 61511, Egypt.
Walaa Yehia AbdelzaherDepartment of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61511, Egypt. walaa.hamada@mu.edu.eg.ORCID http://orcid.org/0000-0001-6511-1797

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is limited data regarding the hazardous effect of gentamicin (GM) on the uterus and whether or not vinpocetine (Vinpo) ameliorates it. The present study aimed to identify the possible protective effect of Vinpo in GM-induced uterine injury in rats.

methodsFemale rats were assorted in control-group, Vinpo-group, GM-group, and Vinpo plus GM group. Serum and uterine GM concentration were measured. Uterine oxidative stress parameters besides inflammatory and apoptotic biomarkers were evaluated. Uterine histopathological examination and interlukin-1beta (IL-1β) immune-histochemical study were detected.

resultsGM significantly increased uterine oxidative stress, inflammatory and apoptotic biomarkers. Histopathological picture of uterine damage and increased IL-1β immunoexpression were detected. Vinpo significantly ameliorated the distributed GM concentration, oxidative stress, inflammatory and apoptotic biomarkers with a prompt improvement in histopathological picture and a decrease in IL-1β immunoexpression.

conclusionVinpo protective effect against GM-induced uterine injury involves modulation of inflammasome/caspase-1/IL-1β signaling pathway.

Indexed as

Caspase 1GentamicinsInflammasomesInterleukin-1betaOxidative StressSignal TransductionUterusVinca AlkaloidsAnimalsApoptosisFemaleRatsCaspase 1GentamicinsIL1B protein, ratInflammasomesInterleukin-1betaVinca AlkaloidsvinpocetineCaspase-1GentamicinInflammasomeUterine injuryVinpocetine

Identifiers

PMID38739285

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.