Evidence map›Paper›PMID 38739251›Full record

ArticleNeuroscience bulletin2024

Thalamic Nucleus Reuniens Glutamatergic Neurons Mediate Colorectal Visceral Pain in Mice via 5-HT

Di Li, Han Du, Shu-Ting Qu, Jing-Lai Wu, Yong-Chang Li, Qi-Ya Xu, Xia Chen, Xiao-Xuan Dai, Ji-Tian Xu, Qian Wang and 1 more

Abstract read
In one paragraph

Article in Neuroscience bulletin, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Targeting the 5-HTCell & bioscience · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Di Li *Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.ORCID https://orcid.org/0000-0003-3423-9047
Han Du *Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Shu-Ting Qu *Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215123, China.
Jing-Lai WuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Yong-Chang LiJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Qi-Ya XuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Xia ChenDepartment of Anesthesiology, Children's Hospital of Soochow University, Suzhou, 215123, China.
Xiao-Xuan DaiJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Ji-Tian XuDepartment of Physiology and Neurobiology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Qian WangDepartment of Anesthesiology, Children's Hospital of Soochow University, Suzhou, 215123, China. q_wang0302@suda.edu.cn.ORCID https://orcid.org/0000-0003-4531-9499
Guang-Yin XuJiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, 215123, China. guangyinxu@suda.edu.cn.ORCID https://orcid.org/0000-0002-5465-5892

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irritable bowel syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity. Reducing visceral hypersensitivity is the key to effectively relieving abdominal pain in IBS. Increasing evidence has confirmed that the thalamic nucleus reuniens (Re) and 5-hydroxytryptamine (5-HT) neurotransmitter system play an important role in the development of colorectal visceral pain, whereas the exact mechanisms remain largely unclear. In this study, we found that high expression of the 5-HT

Indexed as

NeuronsReceptor, Serotonin, 5-HT2BVisceral PainAnimalsAnimals, NewbornColonGlutamic AcidHyperalgesiaMaleMaternal DeprivationMiceMice, Inbred C57BLProto-Oncogene Proteins c-fosRectumVentral Thalamic NucleiGlutamic AcidProto-Oncogene Proteins c-fosReceptor, Serotonin, 5-HT2B5-HT2B receptorsColorectal visceral painGlutamatergic neuronsNeonatal maternal deprivationThalamic nucleus reuniens

Identifiers

PMID38739251
PMCPMC11422542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.