Evidence map›Paper›PMID 38738814›Full record

ArticleJournal of cardiovascular electrophysiology2024

Automated prediction of isthmus areas in scar-related atrial tachycardias using artificial intelligence.

Deepak Saluja, Ziyi Huang, Jonah Majumder, Lawrence Zeldin, Hirad Yarmohammadi, Angelo Biviano, Elaine Y Wan, Edward J Ciaccio, Christine P Hendon, Hasan Garan

Abstract read
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Automated analysis of electrogram characteristics in baseline rhythm can distinguish isthmus regions and segments in reentrant ventricular tachycardia.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  3. [Atrial tachycardia after previous ablation-right atrial, left atrial, biatrial].Herzschrittmachertherapie & Elektrophysiologie · 2026
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deepak SalujaDivision of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.ORCID 0000-0002-8258-4374
Ziyi HuangDepartment of Electrical Engineering, Fu Foundation School of Engineering and Applied Science (SEAS), Columbia University, New York, New York, USA.
Jonah MajumderDepartment of Biomedical Engineering, Fu Foundation School of Engineering and Applied Science (SEAS), Columbia University, New York, New York, USA.
Lawrence ZeldinDepartment of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Hirad YarmohammadiDivision of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.ORCID 0000-0002-6072-5834
Angelo BivianoDivision of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Elaine Y WanDivision of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.ORCID 0000-0002-5328-7282
Edward J CiaccioDivision of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
Christine P HendonDepartment of Biomedical Engineering, Fu Foundation School of Engineering and Applied Science (SEAS), Columbia University, New York, New York, USA.
Hasan GaranDivision of Cardiology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.

Funding

Medical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3M
Optically guided catheter ablation of atrial fibrillationR01HL149369 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI HENDON, CHRISTINE P, LAURITA, KENNETH · 2019 to 2022
$2.8M
Understanding the role of mitochondrial dysfunction in cardiac arrhythmias using a novel 3D panoramic optical mapping systemR01HL152236 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAN, ELAINE Y · 2020 to 2024
$2.0M
Columbia University SEAS Translational Acceleration Research Award 360237808 (CPH and DS).NHLBI NIH HHS R01 HL149369NHLBI NIH HHS R01 HL152236NIGMS NIH HHS T32 GM145440NIH R01HL149369 (CPH)NIH R01HL152236 (EYW)
6 · The paper itself

Abstract

introductionAblation of scar-related reentrant atrial tachycardia (SRRAT) involves identification and ablation of a critical isthmus. A graph convolutional network (GCN) is a machine learning structure that is well-suited to analyze the irregularly-structured data obtained in mapping procedures and may be used to identify potential isthmuses.

methodsElectroanatomic maps from 29 SRRATs were collected, and custom electrogram features assessing key tissue and wavefront properties were calculated for each point. Isthmuses were labeled off-line. Training data was used to determine the optimal GCN parameters and train the final model. Putative isthmus points were predicted in the training and test populations and grouped into proposed isthmus areas based on density and distance thresholds. The primary outcome was the distance between the centroids of the true and closest proposed isthmus areas.

resultsA total of 193 821 points were collected. Thirty isthmuses were detected in 29 tachycardias among 25 patients (median age 65.0, 5 women). The median (IQR) distance between true and the closest proposed isthmus area centroids was 8.2 (3.5, 14.4) mm in the training and 7.3 (2.8, 16.1) mm in the test group. The mean overlap in areas, measured by the Dice coefficient, was 11.5 ± 3.2% in the training group and 13.9 ± 4.6% in the test group.

conclusionA GCN can be trained to identify isthmus areas in SRRATs and may help identify critical ablation targets.

Indexed as

Action PotentialsCatheter AblationCicatrixElectrophysiologic Techniques, CardiacHeart RatePredictive Value of TestsTachycardia, SupraventricularAgedAutomationFemaleHumansMachine LearningMaleMiddle AgedSignal Processing, Computer-AssistedTreatment Outcomeatrial tachycardiaelectroanatomic mappingisthmusmachine learningneural network

Identifiers

PMID38738814
PMCPMC11239288

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.