Evidence map›Paper›PMID 38738584›Full record

ArticleAdvanced healthcare materials2024

A Pseudo-Surfactant Chemical Permeation Enhancer to Treat Otitis Media via Sustained Transtympanic Delivery of Antibiotics.

Sophie S Liu, Joanna M White, Zhongmou Chao, Ruye Li, Shuxian Wen, Ally Garza, Wenjing Tang, Xiaojing Ma, Pengyu Chen, Susan Daniel and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sophie S LiuRobert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA.ORCID 0000-0002-6616-1339
Joanna M WhiteDepartment of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Ave., Minneapolis, MN, 55455, USA.ORCID 0000-0002-5323-4332
Zhongmou ChaoRobert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA.ORCID 0000-0002-9882-4440
Ruye LiDepartment of Chemistry and Chemical Biology, Cornell University, Baker Laboratory, Ithaca, NY, 14850, USA.ORCID 0000-0002-2872-3273
Shuxian WenRobert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA.ORCID 0000-0001-5779-7397
Ally GarzaDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley 1201 W University Drive, Edinburg, TX, 78539, USA.ORCID 0000-0003-0129-279X
Wenjing TangRobert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA.
Xiaojing MaRobert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA.
Pengyu ChenRobert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA.
Susan DanielRobert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA.ORCID 0000-0001-7773-0835
Frank S BatesDepartment of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Ave., Minneapolis, MN, 55455, USA.ORCID 0000-0003-3977-1278
Jingjie YeoSibley School of Mechanical and Aerospace Engineering, Cornell University, Upson Hall, Ithaca, NY, 14850, USA.ORCID 0000-0002-6462-7422
Michelle A CalabreseDepartment of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Ave., Minneapolis, MN, 55455, USA.ORCID 0000-0003-4577-6999
Rong YangRobert F. Smith School of Chemical and Biomolecular Engineering, Cornell University, Olin Hall, Ithaca, NY, 14850, USA.ORCID 0000-0001-6427-026X

Funding

Designing non-toxic hydrogels for trans-tympanic drug delivery and treatment of otitis mediaR21DC019184 · NIDCD · UNIVERSITY OF MINNESOTA · PI CALABRESE, MICHELLE A · 2021 to 2023
$456k
National Nanotechnology Coordinated Infrastructure (NNCI)National Science Foundation NNCI-2025233National Science Foundation Graduate Research Fellowship Program 2237827Natural Sciences and Engineering Research Council of CanadaNIDCD NIH HHS R21 DC019184NIDCD NIH HHS R21DC019184NNCI ECCS-2025124Partnership for Research and Education in Materials within the National Science Foundation DMR-2122178
6 · The paper itself

Abstract

Chemical permeation enhancers (CPEs) represent a prevalent and safe strategy to enable noninvasive drug delivery across skin-like biological barriers such as the tympanic membrane (TM). While most existing CPEs interact strongly with the lipid bilayers in the stratum corneum to create defects as diffusion paths, their interactions with the delivery system, such as polymers forming a hydrogel, can compromise gelation, formulation stability, and drug diffusion. To overcome this challenge, differing interactions between CPEs and the hydrogel system are explored, especially those with sodium dodecyl sulfate (SDS), an ionic surfactant and a common CPE, and those with methyl laurate (ML), a nonionic counterpart with a similar length alkyl chain. Notably, the use of ML effectively decouples permeation enhancement from gelation, enabling sustained delivery across TMs to treat acute otitis media (AOM), which is not possible with the use of SDS. Ciprofloxacin and ML are shown to form a pseudo-surfactant that significantly boosts transtympanic permeation. The middle ear ciprofloxacin concentration is increased by 70-fold in vivo in a chinchilla AOM model, yielding superior efficacy and biocompatibility than the previous highest-performing formulation. Beyond improved efficacy and biocompatibility, this single-CPE formulation significantly accelerates its progression toward clinical deployment.

Indexed as

Anti-Bacterial AgentsChinchillaCiprofloxacinOtitis MediaSurface-Active AgentsTympanic MembraneAnimalsDrug Delivery SystemsHydrogelsPermeabilitySodium Dodecyl SulfateAnti-Bacterial AgentsCiprofloxacinHydrogelsSodium Dodecyl SulfateSurface-Active Agentsdrug deliveryhydrogelsmethyl laurateOtitis mediapermeation enhancers

Identifiers

PMID38738584
PMCPMC11368652

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.