Evidence map›Paper›PMID 38737747›Full record

ArticlePeerJ2024

Effect of iron saturation of bovine lactoferrin on the inhibition of hepatitis B virus

Haibo Zhou, Yiwei Zhu, Ning Liu, Wencui Zhang, Jianchun Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haibo Zhou *College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang Province, China.
Yiwei Zhu *Chongqing Food Industry Research Institute Co., Ltd., Chongqing, China.
Ning LiuCollege of Food Science, Northeast Agricultural University, Harbin, Heilongjiang Province, China.
Wencui ZhangInstitute of Endemic Diseases, Harbin Center for Disease Control and Prevention, Harbin, Heilongjiang Province, China.
Jianchun HanCollege of Food Science, Northeast Agricultural University, Harbin, Heilongjiang Province, China.

Funding

Research Project of Health and Family Planning Commission of Heilongjiang ProvinceRuikangyuan Ltd. Co
6 · The paper itself

Abstract

Background: Hepatitis B virus (HBV) infection poses a major public health problem worldwide. Bovine lactoferrin (bLf) is a natural product that can inhibit HBV, but the effect of iron saturation on its resistance to HBV is unknown. Aims: The purpose of this study is to investigate the impact of iron saturation of bLf against HBV. Methods: HepG2 cells were cultured in DMEM high glucose containing 10% inactivated fetal calf serum, at 37 °C, in 5% CO Results: The TC Conclusion: A total of 1.5 mg/ml bLf and 0.1 mg/ml holo-bLf could inhibit HBV-DNA in HepG2 cells. Complete bLf structure, appropriate concentration and iron saturation of bLf are necessary conditions for anti-HBV effects.

Indexed as

Antiviral AgentsHepatitis B virusIronLactoferrinAnimalsCattleDNA, ViralHep G2 CellsHumansAntiviral AgentsDNA, ViralIronLactoferrinBovine lactoferrinHepatitis B virusHepG2 cellIron saturationPolymerase chain reaction

Identifiers

PMID38737747
PMCPMC11086297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.