Evidence map›Paper›PMID 38737662›Full record

ArticleJournal of medicine and life2024

Comparing the biological activity and composition of Cerebrolysin with other peptide preparations.

Lisa-Franziska Seidl, Ludwig Aigner

Registry-linked trialAbstract readComparative Study
In one paragraph

Article in Journal of medicine and life, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06677502 (The Usefulness of Cerebrolysin in Alleviating the Severity of Delirium in Critically Ill Patients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06677502 naenrolling by invitationnot on this map

The Usefulness of Cerebrolysin in Alleviating the Severity of Delirium in Critically Ill Patients

TypeinterventionalSponsorMedical University of LublinRan2024 to 2025Enrolled500ConditionsCognitive ImpairmentArmsCerebrolysin, Saline Solution - IV
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biomimetic materials for medical applications.Chinese medical journal · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lisa-Franziska SeidlInstitute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria.
Ludwig AignerInstitute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurological disorders, ranging from acute forms such as stroke and traumatic brain injury to neurodegenerative diseases like dementia, are the leading cause of disability-adjusted life years (DALYs) worldwide. A promising approach to address these conditions and promote nervous system regeneration is the use of the neuropeptide preparation Cerebrolysin, which has been shown to be effective in both clinical and preclinical studies. Despite claims of similar clinical efficacy and safety by several peptide preparations, concerns regarding their generic composition and efficacy have been previously raised. Based on these reports, we analyzed the peptide composition and neurotrophic activity of several peptide preparations allegedly similar to Cerebrolysin and approved in some countries for treating neurological diseases. Our results demonstrate that these preparations lack relevant biological activity and that the peptide composition is significantly different from Cerebrolysin. peptide.

Indexed as

Amino AcidsPeptidesAnimalsHumansNeuroprotective AgentsAmino AcidscerebrolysinNeuroprotective AgentsPeptidesbioassayCerebrolysincerebroprotein hydrolysateDALYsDisability-Adjusted Life YearsEGFPEnhanced Green Fluorescent ProteinHigh Performance Liquid ChromatographyHPLCNeurofilament-Lneuronal differentiationNF-LPC12porcine brainRat Pheochromocytoma Cell Line

Identifiers

PMID38737662
PMCPMC11080511

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.