Evidence map›Paper›PMID 38737633›Full record

ArticleNano select : open access2022

Delivery and actuation of aerosolized microbots.

Coy J Zimmermann, Tyler Schraeder, Brandon Reynolds, Emily M DeBoer, Keith B Neeves, David W M Marr

Abstract read
In one paragraph

Article in Nano select : open access, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Coupling magnetic torque and force for colloidal microbot assembly and manipulation.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  4. Review
  5. Paddlebots: Translation of Rotating Colloidal Assemblies near an Air/Water Interface.Langmuir : the ACS journal of surfaces and colloids · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Coy J ZimmermannDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, Colorado 80401, USA.ORCID 0000-0002-0863-0723
Tyler SchraederDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, Colorado 80401, USA.
Brandon ReynoldsDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, Colorado 80401, USA.
Emily M DeBoerDepartment of Pediatrics, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado 80045, USA.
Keith B NeevesDepartments of Bioengineering and Pediatrics, Hemophilia and Thrombosis Center, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado 80045, USA.
David W M MarrDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, Colorado 80401, USA.

Funding

Magnetically propelled microwheels for rapid thrombolysis in small arteriesR01NS102465 · NINDS · COLORADO SCHOOL OF MINES · PI MARR, DAVID WM, NEEVES, KEITH B · 2018 to 2022
$2.6M
Airborne delivery of microbots for chemical and mechanical attack of pulmonary biofilmsR21AI138214 · NIAID · COLORADO SCHOOL OF MINES · PI MARR, DAVID WM, NEEVES, KEITH B · 2019 to 2020
$419k
NIAID NIH HHS R21 AI138214NINDS NIH HHS R01 NS102465
6 · The paper itself

Abstract

For disease of the lung, the physical key to effective inhalation-based therapy is size; too large (10's of μm) and the particles or droplets do not remain suspended in air to reach deep within the lungs, too small (subμm) and they are simply exhaled without deposition. μBots within this ideal low-μm size range however are challenging to fabricate and would lead to devices that lack the speed and power necessary for performing work throughout the pulmonary network. To uncouple size from structure and function, here we demonstrate an approach where individual building blocks are aerosolized and subsequently assembled in situ into μbots capable of translation, drug delivery, and mechanical work deep within lung mimics. With this strategy, a variety of pulmonary diseases previously difficult to treat may now be receptive to μbot-based therapies.

Indexed as

Aerosolizationcolloidsmicrobots

Identifiers

PMID38737633
PMCPMC11086685

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.