ArticleJournal of the Endocrine Society2024
Pitfalls in the Diagnostic Evaluation of Pheochromocytomas.
Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Sweet syndrome with reactive lymphadenopathy mimicking metastatic disease in anJCEM case reports · 2026Article
- Urinary Normetanephrine for the Diagnosis of Canine Pheochromocytoma via Liquid Chromatography-Mass Spectrometry.Veterinary sciences · 2026Article
- Utility ofIrish veterinary journal · 2025Article
- Biogenic amine testing in the South African public health care system.Practical laboratory medicine · 2025Article
- Biochemically Negative Pheochromocytoma With Spontaneous Hemorrhage.AACE endocrinology and diabetesArticle
- Portrait of a Series of Patients with Pheochromocytoma/Paraganglioma from a Reference Center in Brazil: Relevance of Prior Background Features.International braz j urol : official journal of the Brazilian Society of UrologyArticle
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Authors and funding
2 authors.
Funding
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Abstract
Pheochromocytomas and paragangliomas (PPGLs), rare neuroendocrine tumors arising from chromaffin cells, present a significant diagnostic challenge due to their clinical rarity and polymorphic symptomatology. The clinical cases demonstrate the importance of an integrated approach that combines clinical assessment, biochemical testing, and imaging to distinguish PPGLs from mimicking conditions, such as obstructive sleep apnea and interfering medication effects, which can lead to false-positive biochemical results. Although a rare condition, false-negative metanephrine levels can occur in pheochromocytomas, but imaging findings can give some clues and increase suspicion for a pheochromocytoma diagnosis. This expert endocrine consult underscores the critical role of evaluating preanalytical conditions and pretest probability in the biochemical diagnosis of PPGLs. Moreover, a careful differentiation of PPGLs from similar conditions and careful selection and interpretation of diagnostic tests, with focus on understanding and reducing false positives to enhance diagnostic accuracy and patient outcomes, is crucial.
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