Evidence map›Paper›PMID 38737298›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2024

Association Analysis of Essential Tremor-Associated Genetic Variants in Sporadic Late-Onset Parkinson's Disease.

Sheng Zeng, Xun Zhou, Runcheng He, Yuwen Zhao, Zhenhua Liu, Qian Xu, Jifeng Guo, Xinxiang Yan, Jinchen Li, Beisha Tang and 1 more

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Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. An Exploratory Analysis of Essential Tremor and Associated Phenotypes.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026
    Article
4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Sheng ZengDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.ORCID 0000-0003-4239-7854
Xun ZhouDepartment of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.ORCID 0000-0002-7325-5720
Runcheng HeDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0001-9317-1746
Yuwen ZhaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0002-3565-3592
Zhenhua LiuKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0003-0031-5646
Qian XuKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0002-5223-9967
Jifeng GuoKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0002-3658-3928
Xinxiang YanKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0002-4367-7105
Jinchen LiKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0001-5522-806X
Beisha TangKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0003-2120-1576
Qiying SunKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0002-2031-8345

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Parkinson's disease (PD) and Essential tremor (ET) are the two most common tremor diseases with recognized genetic pathogenesis. The overlapping clinical features suggest they may share genetic predispositions. Our previous study systematically investigated the association between rare coding variants in ET-associated genes and early-onset PD (EOPD), and found the suggestive association between Methods: We performed whole-genome sequencing in the 1962 sporadic LOPD cases and 1279 controls from mainland China. We first used logistic regression analysis to test the top 16 SNPs identified by the ET genome-wide association study for the association between ET and LOPD. Then we applied the optimized sequence kernel association testing to explore the rare variant burden of 33 ET-associated genes in this cohort. Results: We did not observe a significant association between the included SNPs with LOPD. We also did not discover a significant burden of rare deleterious variants of ET-associated genes in association with LOPD risk. Conclusion: Our results do not support the role of ET-associated genetic loci and variants in LOPD. Highlights: 1962 cases and 1279 controls were recruited to study the potential genetic interplay between ET-associated genetic loci/variants and sporadic LOPD.No significant association between the ET-associated SNPs and LOPD were observed.No significant burden of rare deleterious variants of ET-associated gene in LOPD risk were found.

Indexed as

Essential TremorGenetic Predisposition to DiseaseGenome-Wide Association StudyParkinson DiseasePolymorphism, Single NucleotideAgedAge of OnsetCase-Control StudiesChinaFemaleHumansMaleMiddle Agedassociation analysisessential tremorgenetic variantParkinson’s diseaserare deleterious variantsSKAT-O

Identifiers

PMID38737298
PMCPMC11086585

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.