Evidence map›Paper›PMID 38736751›Full record

ReviewFrontiers in cellular and infection microbiology2024

Roles of airway and intestinal epithelia in responding to pathogens and maintaining tissue homeostasis.

Marcela Ambrogi, Chad M Vezina

Abstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Evaluation ofMicroorganisms · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. How Delayed Cord Clamping Saves Newborn Lives.Children (Basel, Switzerland) · 2025
    Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marcela AmbrogiDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Chad M VezinaDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.

Funding

Integrated Program in Endocrinology Translational Postdoctoral Training ProgramT32HD101384 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI IAN M. BIRD, Jon E Levine · 2021 to 2026
$2.0M
NICHD NIH HHS T32 HD101384
6 · The paper itself

Abstract

Epithelial cells form a resilient barrier and orchestrate defensive and reparative mechanisms to maintain tissue stability. This review focuses on gut and airway epithelia, which are positioned where the body interfaces with the outside world. We review the many signaling pathways and mechanisms by which epithelial cells at the interface respond to invading pathogens to mount an innate immune response and initiate adaptive immunity and communicate with other cells, including resident microbiota, to heal damaged tissue and maintain homeostasis. We compare and contrast how airway and gut epithelial cells detect pathogens, release antimicrobial effectors, collaborate with macrophages, Tregs and epithelial stem cells to mount an immune response and orchestrate tissue repair. We also describe advanced research models for studying epithelial communication and behaviors during inflammation, tissue injury and disease.

Indexed as

HomeostasisImmunity, InnateIntestinal MucosaAdaptive ImmunityAnimalsEpithelial CellsHost-Pathogen InteractionsHumansMacrophagesRespiratory MucosaSignal Transductionbarrier integrityepithelial homeostasisimmune signalingpathogen detectiontissue repair

Identifiers

PMID38736751
PMCPMC11082347

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.