ArticleCurrent directions in psychological science2019
Phenotypic Annotation: Using Polygenic Scores to Translate Discoveries From Genome-Wide Association Studies From the Top Down.
Article in Current directions in psychological science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Gene-environment interplay explaining individual variation in BMI outcomes: a systematic review and meta-analysis of studies using polygenic indices.International journal of obesity (2005) · 2026Pooled it
- Overcoming attenuation bias in regressions using polygenic indices.Nature communications · 2023Pooled it
- Genetics of Educational Attainment and Childhood Problem Behavior: Direct Genetic Effects, Cognitive Pathways, and Sex Differences.Behavior genetics · 2026Article
- Non-cognitive skills mediate education-related polygenic score associations with academic achievement across development.Nature communications · 2026Article
- Does bilingualism buffer genetic predispositions to reading difficulties through alterations of structural interhemispheric connectivity? An ABCDbioRxiv : the preprint server for biology · 2026Article
- Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping.Research square · 2025Article
- Genotypic and socioeconomic risks for depressive symptoms in two U.S. cohorts spanning early to older adulthood.Journal of psychopathology and clinical science · 2025Article
- From genetic disposition to academic achievement: The mediating role of non-cognitive skills across development.bioRxiv : the preprint server for biology · 2025Article
- A Litmus Test for Confounding in Polygenic Scores.bioRxiv : the preprint server for biology · 2025Article
- The Geneticization of Education and Its Bioethical Implications.Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees · 2024Article
- Exploring the Fetal Origins Hypothesis Using Genetic Data.Social forces; a scientific medium of social study and interpretation · 2024Article
- The Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias.Journal of Alzheimer's disease : JAD · 2024Article
- Interrogating the validity of cumulative indices of environmental and genetic risk for negative developmental outcomes.Development and psychopathology · 2023Article
- Associating broad and clinically defined polygenic scores for depression with depression-related phenotypes.Scientific reports · 2023Article
- GeneralPsychological medicine · 2023Article
- Polygenic indices for cognition in healthy aging; the role of brain measures.Neuroimage. Reports · 2023Article
- Toward a better understanding of the causal effects of role demands on work-family conflict: A genetic modeling approach.The Journal of applied psychology · 2023Article
- Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals.Biological psychiatry · 2022Article
- Barriers to genetic testing in clinical psychiatry and ways to overcome them: from clinicians' attitudes to sociocultural differences between patients across the globe.Translational psychiatry · 2022Review
- An in-laboratory stressor reveals unique genetic variation in child cortisol output.Developmental psychology · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Genome-wide association studies (GWASs) have identified specific genetic variants associated with complex human traits and behaviors, such as educational attainment, mental disorders, and personality. However, small effect sizes for individual variants, uncertainty regarding the biological function of discovered genotypes, and potential "outside-the-skin" environmental mechanisms leave a translational gulf between GWAS results and scientific understanding that will improve human health and well-being. We propose a set of social, behavioral, and brain-science research activities that map discovered genotypes to neural, developmental, and social mechanisms and call this research program
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.