Evidence map›Paper›PMID 38736688›Full record

ArticleTetrahedron letters2024

Squaric esters as peptide stapling reagents.

Adam X Wayment, Nye C Johnson, Mariur Rodriguez Moreno, Christopher Stewart, Braxton M Felix, Isaac Lambert, Sarah A Traynor, P Michael Nielson, Grant Q Lofgreen, Shannon L Smith and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Adam X WaymentDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Nye C JohnsonDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Mariur Rodriguez MorenoDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Christopher StewartDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Braxton M FelixDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Isaac LambertDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Sarah A TraynorDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
P Michael NielsonDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Grant Q LofgreenDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Shannon L SmithDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Madison P NewtonDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Jordan W TretbarDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Joseph M L NygaardDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Kylie G HarrellDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
Michael J KinghornDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.
David J MichaelisDepartment of Chemsitry and Biochemistry, Brigham Young University, Provo, UT, USA.

Funding

Multifunctional enzyme-like catalysts for organic synthesisR15GM134476 · NIGMS · BRIGHAM YOUNG UNIVERSITY · PI MICHAELIS, DAVID JOHN · 2019 to 2019
$437k
NIGMS NIH HHS R15 GM134476
6 · The paper itself

Abstract

We report that squaric esters can serve as bifunctional reagents for selective peptide stapling reactions. Formation of the squaric amide staple occurs under mild conditions with amine-containing side chains. We show that short resin-bound peptides are readily stapled on solid phase and that stapling can occur at various relative positions along the peptide and with various amine tether lengths (e.g. Lysine, ornithine, etc). The squaric amide staples are stable to strong acid conditions used to cleave the stapled peptide from the resin and the stapled peptides show an increase in helicity as analyzed through circular dichroism.

Identifiers

PMID38736688
PMCPMC11087058

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.