Evidence map›Paper›PMID 38736551›Full record

ArticleiScience2024

Antimicrobial peptide LL37 and regulatory T cell associated with late-onset sepsis in very preterm infants.

Ren Zhuxiao, Yang Shuo, Han Jiangxue, Pei Jingjun, Zhang Qi, Wang Zhu, Xu Fang, Yang Jie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ren ZhuxiaoDepartment of Neonatology, Guangdong Women and Children Hospital, Guangzhou, China.
Yang ShuoDepartment of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Han JiangxueDepartment of Neonatology, Guangdong Women and Children Hospital, Guangzhou, China.
Pei JingjunDepartment of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhang QiDepartment of Clinical Genetic Center, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, China.
Wang ZhuDepartment of Neonatology, Guangdong Women and Children Hospital, Guangzhou, China.
Xu FangDepartment of Neonatology, Guangdong Women and Children Hospital, Guangzhou, China.
Yang JieDepartment of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cell therapy may prevent late-onset sepsis (LOS) via antimicrobial peptide LL37 secretion and regulatory T cell (Treg) regulation. The early prediction of LOS is still a challenge. This study evaluated whether immunological state of LL37 or Tregs precedes LOS. We firstly analyzed the LL37 level, Treg proportion, and LOS incidence in very preterm infants treated with autologous cord blood mononuclear cells (ACBMNCs) in our previous trial. Then, we constructed a prediction model and built validation cohort. We found ACBMNC intervention reduced the incidence of LOS from 27.3% to 6.9% (

Indexed as

Cell biologyHealth sciencesImmunologyStem cells research

Identifiers

PMID38736551
PMCPMC11088333

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.