Evidence map›Paper›PMID 38736470›Full record

ArticleJournal of respiratory biology and translational medicine2024

Arrestin beta 1 Regulates Alveolar Progenitor Renewal and Lung Fibrosis.

Guanling Huang, Yan Geng, Vrishika Kulur, Ningshan Liu, Xue Liu, Forough Taghavifar, Jiurong Liang, Paul W Noble, Dianhua Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of respiratory biology and translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guanling HuangDivision of Pulmonary, Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Yan GengDivision of Pulmonary, Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Vrishika KulurDivision of Pulmonary, Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Ningshan LiuDivision of Pulmonary, Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Xue LiuDivision of Pulmonary, Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Forough TaghavifarDivision of Pulmonary, Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Jiurong LiangDivision of Pulmonary, Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Paul W NobleDivision of Pulmonary, Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Dianhua JiangDivision of Pulmonary, Women's Guild Lung Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Funding

Role of Surfactant Proteins in Mediating Noninfectious Inflammatory and FibroproP01HL108793 · NHLBI · DUKE UNIVERSITY · PI NOBLE, PAUL WESLEY · 2012 to 2022
$21.3M
Molecular Regulation of Progressive Pulmonary FibrosisR35HL150829 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Paul Wesley Noble · 2020 to 2026
$5.7M
ZIP8-dependent Zinc Metabolic Regulation in Alveolar Progenitor Cell Aging and FibrosisR01AG078655 · NIA · CEDARS-SINAI MEDICAL CENTER · PI Carol Jiurong Liang, Paul Wesley Noble · 2022 to 2026
$2.7M
Targeting WNT7A Signaling in Pulmonary FibrosisR01HL172990 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Dianhua Jiang · 2024 to 2026
$2.3M
Targeting beta-arrestins in Pulmonary FibrosisR01HL122068 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI JIANG, DIANHUA, NOBLE, PAUL WESLEY · 2015 to 2018
$2.1M
NHLBI NIH HHS P01 HL108793NHLBI NIH HHS R01 HL122068NHLBI NIH HHS R01 HL172990NHLBI NIH HHS R35 HL150829NIA NIH HHS R01 AG078655
6 · The paper itself

Abstract

The molecular mechanisms that regulate progressive pulmonary fibrosis remain poorly understood. Type 2 alveolar epithelial cells (AEC2s) function as adult stem cells in the lung. We previously showed that there is a loss of AEC2s and a failure of AEC2 renewal in the lungs of idiopathic pulmonary fibrosis (IPF) patients. We also reported that beta-arrestins are the key regulators of fibroblast invasion, and beta-arrestin 1 and 2 deficient mice exhibit decreased mortality, decreased matrix deposition, and increased lung function in bleomycin-induced lung fibrosis. However, the role of beta-arrestins in AEC2 regeneration is unclear. In this study, we investigated the role and mechanism of Arrestin beta 1 (ARRB1) in AEC2 renewal and in lung fibrosis. We used conventional deletion as well as cell type-specific deletion of

Indexed as

AEC2Alveolar stem cellArrb1CCL7FibrosisIPFLungStem cell

Identifiers

PMID38736470
PMCPMC11087074

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.