Evidence map›Paper›PMID 38736378›Full record

ReviewJournal of mass spectrometry : JMS2024

Direct sub-atmospheric pressure ionization mass spectrometry: Evaporation/sublimation-driven ionization is amazing, fundamentally, and practically.

Sarah Trimpin, Ellen D Inutan, Vincent S Pagnotti, Santosh Karki, Darrell D Marshall, Khoa Hoang, Beixi Wang, Christopher B Lietz, Alicia L Richards, Frank S Yenchick and 22 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of mass spectrometry : JMS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Sarah TrimpinDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0002-3720-2269
Ellen D InutanDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Vincent S PagnottiDepartment of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA.
Santosh KarkiDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Darrell D MarshallDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Khoa HoangMSTM, LLC, Newark, Delaware, USA.
Beixi WangDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Christopher B LietzDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Alicia L RichardsDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Frank S YenchickDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Chuping LeeDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
I-Chung LuDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.ORCID https://orcid.org/0000-0002-3125-6397
Madeleine FennerDepartment of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA.
Sara MadarshahianDepartment of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA.
Sarah SaylorDepartment of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA.
Nicolas D ChubatyiDepartment of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA.
Teresa ZimmermanDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Abigail Moreno-PedrazaDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Tongwen WangDepartment of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA.
Adetoun Adeniji-AdeleDepartment of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA.
Anil K MeherDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Hasini MadagedaraDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Zachary OwczarzakDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Ahmed MusaviDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Tamara L HendricksonDepartment of Chemistry, Wayne State University, Detroit, Michigan, USA.
Patricia M PeacockFirst State IR, LLC, Hockessin, Delaware, USA.
John W TomshoDepartment of Chemistry & Biochemistry, Saint Joseph's University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-9972-8728
Barbara S LarsenMSTM, LLC, Newark, Delaware, USA.
Laszlo ProkaiDepartment of Pharmacology and Neuroscience, The University of North Texas Health Science Center at Forth Worth, Fort Worth, Texas, USA.
Vladimir ShulaevDepartment of Biological Sciences, The University of North Texas, Denton, Texas, USA.
Milan PophristicMSTM, LLC, Newark, Delaware, USA.
Charles N McEwenMSTM, LLC, Newark, Delaware, USA.

Funding

Development of multimode vacuum ionization for use in medical diagnosticsR43AI172667 · NIAID · MSTM, LLC · PI MCEWEN, CHARLES N · 2023 to 2023
$159k
NIAID NIH HHS R43 AI172667NIH HHS
6 · The paper itself

Abstract

This paper covers direct sub-atmospheric pressure ionization mass spectrometry (MS). The discovery, applications, and mechanistic aspects of novel ionization processes for use in MS that are not based on the high-energy input from voltage, laser, and/or high temperature but on sublimation/evaporation within a region linking a higher to lower pressure and modulated by heat and collisions, are discussed, including how this new reality has guided a series of discoveries, instrument developments, and commercialization. A research focus, inter alia, is on how best to understand, improve, and use these novel ionization processes, which convert volatile and nonvolatile compounds from solids (sublimation) or liquids (evaporation) into gas-phase ions for analysis by MS providing reproducible, accurate, sensitive, and prompt results. Our perception on how these unprecedented versus traditional ionization processes/methods relate to each other, how they can be made to coexist on the same mass spectrometer, and an outlook on new and expanded applications (e.g., clinical, portable, fast, safe, and autonomous) is presented, and is based on ST's Opening lecture presentation at the Nordic Mass spectrometry Conference, Geilo, Norway, January 2023. Focus will be on matrix-assisted ionization (MAI) and solvent-assisted ionization (SAI) MS covering the period from 2010 to 2023; a potential paradigm shift in the making.

Indexed as

direct ionization mass spectrometryfastnovice userrobustsafetysensitivesub‐atmospheric pressure ionization mass spectrometrysublimation/evaporation‐driven ionization

Identifiers

PMID38736378
PMCPMC12105868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.