ArticleAddiction (Abingdon, England)2024
Incident psychotic experiences following self-reported use of high-potency cannabis: Results from a longitudinal cohort study.
Article in Addiction (Abingdon, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Effects of legal access versus illegal market cannabis on use and mental health: A randomized controlled trial.Addiction (Abingdon, England) · 2025Trial
- Influence of cannabis potency on mental health outcomes among adolescents and young adults: scoping review.BJPsych open · 2026Review
- Cannabis use and psychotic-like experiences in themedRxiv : the preprint server for health sciences · 2025Article
- The annual trend of suicide rates from 2010 to 2021 in patients with cannabis use disorder - a national registry study.Social psychiatry and psychiatric epidemiology · 2025Article
- Reply to Zhou et al's "Refining Psychosis Research: Insights on Cannabis Use and Data Accuracy".Schizophrenia bulletin · 2024Article
- Cannabis and Psychosis: Weeding Out Fact from Fiction.Missouri medicineArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
BACKGROUND AND
aimsHigh-potency cannabis has been associated with increased risk of psychosis, but a lack of prospective data hinders understanding of causality in this relationship. This study aimed to combine prospective report of cannabis use with retrospective report of potency to infer the potency of cannabis used in adolescence and explore whether use of cannabis, and the use of high-potency cannabis, in adolescence is associated with incident psychotic experiences.
designPopulation-based birth cohort study.
settingUnited Kingdom.
participantsn = 5570 participants who reported on any cannabis use (yes/no) age 16 and 18 years, and n = 1560 participants from this group who also retrospectively reported on cannabis potency. MEASUREMENTS: In questionnaires at ages 16 and 18, individuals self-reported lifetime cannabis use, and at age 24, participants reported the type of cannabis they most commonly used in the whole time since first using cannabis. Psychotic experiences were assessed at age 24 years using the semi-structured Psychosis-Like Symptom Interview, with incident defined as new-onset occurring between ages 19 and 24 years.
findingsUse of high-potency cannabis at age 16 or 18 was associated with twice the likelihood of experiencing incident psychotic experiences from age 19-24 (Odds Ratio 2.15, 95% Confidence Intervals 1.13-4.06). There was less evidence for an effect of any cannabis use on incident psychotic experiences (Odds Ratio 1.45, 95% Confidence Intervals 0.94-2.12).
conclusionsUse of high-potency cannabis appears to be associated with increased likelihood of psychotic experiences.
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Registered trials
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