Evidence map›Paper›PMID 38735943›Full record

ArticleJournal of biomedical science2024

Excess glucose alone depress young mesenchymal stromal/stem cell osteogenesis and mitochondria activity within hours/days via NAD

B Linju Yen, Li-Tzu Wang, Hsiu-Huang Wang, Chin-Pao Hung, Pei-Ju Hsu, Chia-Chi Chang, Chien-Yu Liao, Huey-Kang Sytwu, Men-Luh Yen

Erratum issuedAbstract read
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In one paragraph

Article in Journal of biomedical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

B Linju Yen *Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), No.35, Keyan Road, Zhunan, 35053, Taiwan. blyen@nhri.edu.tw.
Li-Tzu Wang *Department of Obstetrics & Gynecology, National Taiwan University (NTU) Hospital & College of Medicine, NTU, No.1, Section 1, Jen-Ai Road, Taipei, 10051, Taiwan.
Hsiu-Huang WangRegenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), No.35, Keyan Road, Zhunan, 35053, Taiwan.
Chin-Pao HungDepartment of Obstetrics & Gynecology, National Taiwan University (NTU) Hospital & College of Medicine, NTU, No.1, Section 1, Jen-Ai Road, Taipei, 10051, Taiwan.
Pei-Ju HsuRegenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), No.35, Keyan Road, Zhunan, 35053, Taiwan.
Chia-Chi ChangRegenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), No.35, Keyan Road, Zhunan, 35053, Taiwan.
Chien-Yu LiaoRegenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), No.35, Keyan Road, Zhunan, 35053, Taiwan.
Huey-Kang SytwuNational Institute of Infectious Diseases & Vaccinology, NHRI, No.35, Keyan Road, Zhunan, 35053, Taiwan.
Men-Luh YenDepartment of Obstetrics & Gynecology, National Taiwan University (NTU) Hospital & College of Medicine, NTU, No.1, Section 1, Jen-Ai Road, Taipei, 10051, Taiwan. mlyen@ntu.edu.tw.

Funding

National Health Research Institutes NHRI-11A1-CSGP08-048National Health Research Institutes NHRI-11A1-CSPP06-014National Science and Technology Council MOST-107-2314-B-002-104-MY3National Science and Technology Council MOST-111-2314-B-002-159-MY3
6 · The paper itself

Abstract

backgroundThe impact of global overconsumption of simple sugars on bone health, which peaks in adolescence/early adulthood and correlates with osteoporosis (OP) and fracture risk decades, is unclear. Mesenchymal stromal/stem cells (MSCs) are the progenitors of osteoblasts/bone-forming cells, and known to decrease their osteogenic differentiation capacity with age. Alarmingly, while there is correlative evidence that adolescents consuming greatest amounts of simple sugars have the lowest bone mass, there is no mechanistic understanding on the causality of this correlation.

methodsBioinformatics analyses for energetics pathways involved during MSC differentiation using human cell information was performed. In vitro dissection of normal versus high glucose (HG) conditions on osteo-/adipo-lineage commitment and mitochondrial function was assessed using multi-sources of non-senescent human and murine MSCs; for in vivo validation, young mice was fed normal or HG-added water with subsequent analyses of bone marrow CD45

resultsBioinformatics analyses revealed mitochondrial and glucose-related metabolic pathways as integral to MSC osteo-/adipo-lineage commitment. Functionally, in vitro HG alone without differentiation induction decreased both MSC mitochondrial activity and osteogenesis while enhancing adipogenesis by 8 h' time due to depletion of nicotinamide adenine dinucleotide (NAD

conclusionsWe found a surprisingly rapid impact of excessive glucose, a single dietary factor, on MSC SIRT1 function and osteogenesis in youthful settings, and the crucial role of NAD

Indexed as

GlucoseMesenchymal Stem CellsMitochondriaNADOsteogenesisSirtuin 1AnimalsCell DifferentiationHumansMiceGlucoseNADSIRT1 protein, humanSirt1 protein, mouseSirtuin 1AdipogenesisHigh glucoseHuman mesenchymal stromal/stem cells (MSCs)MitochondriaMouse modelNicotinamide adenine dinucleotide (NAD+)Nicotinamide mononucleotide (NMN)OsteogenesisSirtuin 1 (SIRT1)

Identifiers

PMID38735943
PMCPMC11089752

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.