Evidence map›Paper›PMID 38735862›Full record

ArticleAmerican journal of industrial medicine2024

A pilot study to identify factors associated with frailty within the World Trade Center general responder cohort.

Hannah M Thompson, Erin Thanik, Ahmad Sabra, Fred Ko, William W Hung, Elena Colicino, Roberto G Lucchini, Ghalib Bello, Michael Crane, Susan L Teitelbaum and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of industrial medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hannah M ThompsonDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Erin ThanikDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ahmad SabraGeneral Responder Data Center, Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Fred KoBrookdale Department of Geriatrics and Palliative Medicine, Geriatric, Research, Education and Clinical Center, Icahn School of Medicine at Mount Sinai, James J Peters VA Medical Center, New York, New York, USA.
William W HungBrookdale Department of Geriatrics and Palliative Medicine, Geriatric, Research, Education and Clinical Center, Icahn School of Medicine at Mount Sinai, James J Peters VA Medical Center, New York, New York, USA.
Elena ColicinoDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Roberto G LucchiniDepartment of Environmental Health Sciences, School of Public Health, Florida International University, Miami, Florida, USA.
Ghalib BelloDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-7893-743X
Michael CraneDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Susan L TeitelbaumDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Katherine A OrnsteinJohns Hopkins School of Nursing, Baltimore, Maryland, USA.

Funding

The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Early-life metal exposures, mitochondrial heteroplasmy, and child antibody response to vaccinationR01ES034521 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Colicino, Todd Jusko · 2022 to 2026
$3.0M
Air Particulate Pollution and Stress: Effects and Mechanisms for Long-term Maternal Obesity RisksR01ES032242 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COLICINO, ELENA, WU, HAOTIAN · 2020 to 2024
$2.2M
Training in Environmental NeuroscienceT32ES033955 · NIEHS · FLORIDA INTERNATIONAL UNIVERSITY · PI Timothy Alexander Allen, Roberto G Lucchini · 2023 to 2026
$1.1M
NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES032242NIEHS NIH HHS R01 ES034521NIEHS NIH HHS T32 ES033955NIOSH CDC HHS U01 OH012068NIOSH CDC HHS U01 OH012473
6 · The paper itself

Abstract

backgroundGiven the significant exposures experienced by the World Trade Center (WTC) general responders, there is increasing interest in understanding the effect of these exposures on aging in this population. We aim to identify factors that may be associated with frailty, a clinical syndrome characterized by a decrease in one's reserve that has been linked to poor health outcomes.

methodsWTC general responders enrolled in the WTC Health Program aged 50 and older provided informed consent. Validated frailty assessments, the Frailty Phenotype (with the Johns Hopkins Frailty Assessment Calculator) along with the FRAIL scale, categorized nonfrail from prefrail/frail. Fall risk, functional status, and cognition were also assessed. WTC variables, including an identified WTC-certified condition, were utilized. The risk of frailty was estimated using log binomial regression analysis. A 95% confidence interval (CI) was used to estimate the prevalence ratio (PR).

resultsOne hundred and six participants were included; 38 (35.8%) were classified as pre-frail or frail. More of the pre-frail/frail group were obese (57.9% vs. 25%; p = 0.004) and had a WTC-certified condition (78.9% vs. 58.8%; p = 0.036). Obesity (PR = 2.43, 95% CI = 1.31, 4.53), a WTC-certified condition (PR = 1.77, 95% CI = 1.09, 2.89), and risk of falling (PR = 1.97, 95% CI = 1.01, 3.84) were independently associated with frailty.

conclusionsObesity and having a WTC-certified condition were found to be risk factors for frailty in our pilot study. Future work may focus on further identifying risk factors for frailty in the larger WTC general responder population.

Indexed as

Emergency RespondersFrailtySeptember 11 Terrorist AttacksAccidental FallsAgedCohort StudiesFemaleHumansMaleMiddle AgedNew York CityOccupational ExposurePilot ProjectsPrevalenceRisk Factorsfrailtyfrailty phenotypeobesityworld trade center

Identifiers

PMID38735862
PMCPMC12462526

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.