Evidence map›Paper›PMID 38735682›Full record

ArticleBritish journal of haematology2024

Prevalence of kidney health genetic variants in adults with sickle cell nephropathy.

Maria Armila Ruiz, Xu Zhang, M Adela Mansilla, Rima S Zahr, Christie P Thomas, Richard J Smith, Victor R Gordeuk, Santosh L Saraf

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Armila RuizDivision of Hematology and Oncology, Sickle Cell Center, University of Illinois at Chicago, Chicago, Illinois, USA.
Xu ZhangDivision of Hematology and Oncology, Sickle Cell Center, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-7732-1385
M Adela MansillaDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Rima S ZahrDivision of Pediatric Nephrology and Hypertension, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID https://orcid.org/0000-0002-3631-7195
Christie P ThomasDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Richard J SmithDepartment of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Victor R GordeukDivision of Hematology and Oncology, Sickle Cell Center, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-4725-7295
Santosh L SarafDivision of Hematology and Oncology, Sickle Cell Center, University of Illinois at Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-8584-4194

Funding

Pathways of Cell-Free Hemoglobin in Sickle Cell NephropathyR01HL153161 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SARAF, SANTOSH · 2020 to 2024
$2.0M
NHLBI NIH HHS R01 HL153161
6 · The paper itself

Abstract

The pathophysiology and genetic risk for sickle cell disease (SCD)-related chronic kidney disease (CKD) are not well understood. In 70 adults with SCD-related CKD and without APOL1 inherited in a high-risk pattern, 24 (34%) had pathogenic variants in candidate genes using KidneySeq™. A moderate impact INF2 variant was observed in 20 (29%) patients and those with 3 versus 0-2 pathogenic or moderate impact glomerular genetic variants had higher albuminuria and lower estimated glomerular filtration rate (adjusted p ≤ 0.015). Using a panel of preselected genes implicated in kidney health, we observed several variants in people with sickle cell nephropathy.

Indexed as

Anemia, Sickle CellRenal Insufficiency, ChronicAdultApolipoprotein L1FemaleGenetic Predisposition to DiseaseGenetic VariationGlomerular Filtration RateHumansMaleMiddle AgedPrevalenceAPOL1 protein, humanApolipoprotein L1albuminuriagenetic variantsINF2kidney diseasesickle cell disease

Identifiers

PMID38735682
PMCPMC11245361

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.