Evidence map›Paper›PMID 38735637›Full record

ArticleNeurobiology of learning and memory2024

Pharmacological manipulations of the dorsomedial and dorsolateral striatum during fear extinction reveal opposing roles in fear renewal.

Margaret K Tanner, Alyssa A Hohorst, Jessica D Westerman, Carolina Sanchez Mendoza, Rebecca Han, Nicolette A Moya, Jennifer Jaime, Lareina M Alvarez, Miles Q Dryden, Aleezah Balolia and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of learning and memory, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Margaret K TannerDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Alyssa A HohorstDepartment of Integrative Biology, University of Colorado Denver, Denver, CO, USA.
Jessica D WestermanDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Carolina Sanchez MendozaDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Rebecca HanDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Nicolette A MoyaDepartment of Neuroscience, Northwestern Feinberg School of Medicine, Chicago, IL, USA.
Jennifer JaimeThe Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.
Lareina M AlvarezDepartment of Integrative Biology, University of Colorado Denver, Denver, CO, USA.
Miles Q DrydenDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Aleezah BaloliaNeuroscience Program, University of Colorado Anschutz Medical Campus, Denver, CO, USA.
Remla A AbdulDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Esteban C LoetzDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Benjamin N GreenwoodDepartment of Psychology, University of Colorado Denver, Denver, CO, USA. Electronic address: benjamin.greenwood@ucdenver.edu.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
UC Denver MARC U*STAR Scholars Program SupplementT34GM096958 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ALLEN, RICHARD M, FLORES, SONIA CASTRO · 2013 to 2022
$2.3M
Nigrostriatal Dopaminergic Modulation of Fear ExtinctionR15MH114026 · NIMH · UNIVERSITY OF COLORADO DENVER · PI GREENWOOD, BEN N · 2017 to 2020
$933k
NIDDK NIH HHS P30 DK048520NIGMS NIH HHS T34 GM096958NIMH NIH HHS R15 MH114026
6 · The paper itself

Abstract

Systemic manipulations that enhance dopamine (DA) transmission around the time of fear extinction can strengthen fear extinction and reduce conditioned fear relapse. Prior studies investigating the brain regions where DA augments fear extinction focus on targets of mesolimbic and mesocortical DA systems originating in the ventral tegmental area, given the role of these DA neurons in prediction error. The dorsal striatum (DS), a primary target of the nigrostriatal DA system originating in the substantia nigra (SN), is implicated in behaviors beyond its canonical role in movement, such as reward and punishment, goal-directed action, and stimulus-response associations, but whether DS DA contributes to fear extinction is unknown. We have observed that chemogenetic stimulation of SN DA neurons during fear extinction prevents the return of fear in contexts different from the extinction context, a form of relapse called renewal. This effect of SN DA stimulation is mimicked by a DA D1 receptor (D1R) agonist injected into the DS, thus implicating DS DA in fear extinction. Different DS subregions subserve unique functions of the DS, but it is unclear where in the DS D1R agonist acts during fear extinction to reduce renewal. Furthermore, although fear extinction increases neural activity in DS subregions, whether neural activity in DS subregions is causally involved in fear extinction is unknown. To explore the role of DS subregions in fear extinction, adult, male Long-Evans rats received microinjections of either the D1R agonist SKF38393 or a cocktail consisting of GABA

Indexed as

Corpus StriatumExtinction, PsychologicalFearReceptors, Dopamine D1AnimalsConditioning, ClassicalDopamineDopamine AgonistsDopaminergic NeuronsMaleRatsRats, Long-EvansSubstantia NigraDopamineDopamine AgonistsReceptors, Dopamine D1

Identifiers

PMID38735637
PMCPMC11187715

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.