ArticleHearing research2024
Delayed hearing loss after cochlear implantation: Re-evaluating the role of hair cell degeneration.
Article in Hearing research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Electrically evoked compound action potentials in adult and pediatric cochlear implant users: II. Assessing cochlear nerve health status with the interphase gap effect and the phase locking value.Hearing research · 2026Article
- Evaluating the N1-P2 Interpeak Latency of the eCAP and Its Intertrial Variability as Potential Indicators of Neural Synchrony in the Auditory Nerve of Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- The Interphase Gap Effect in Cochlear Implant Users: Biological Basis, Parameter Selection, Analytical Methods, and Quantitative Scales.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Cochlear Implant Insertion Trauma Is Associated With Spiral Ganglion Neuron "Dead Zones" in the Human.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2026Article
- The Effects of Stimulation Level and Stimulation Rate on Neural Synchrony of the Cochlear Nerve in Postlingually Deafened Adult Cochlear Implant Recipients.Ear and hearing · 2025Article
- Evaluating the N1-P2 interpeak latency of the eCAP and its intertrial variability as potential indicators of neural synchrony in the cochlear nerve of cochlear implant users.medRxiv : the preprint server for health sciences · 2025Article
- Dexamethasone-eluting cochlear implants reduce inflammation and foreign body response in human and murine cochleae.Scientific reports · 2025Article
- Genome-Wide Association Study of Age-Related Hearing Loss in CFW Mice Identifies Multiple Genes and Loci, Including Prkag2.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Exploring the Proteomic Landscape of Cochlear Implant Trauma: An iTRAQ-Based Quantitative Analysis Utilizing an Ex Vivo Model.Journal of clinical medicine · 2025Article
- Towards atraumatic cochlear implant insertion monitoring using a hydraulic-based, cost-effective intracochlear pressure probe.Frontiers in surgery · 2025Article
- Polarity sensitivity to symmetric, biphasic monopolar pulses is not a reliable indicator of peripheral axonal degeneration in human cochlear implant users.Frontiers in audiology and otology · 2025Article
- Does the audiogram shape influence the intracochlear recording of Electrocochleography during and after cochlear implantation?Frontiers in neuroscience · 2024Article
- Article
- The Failure Index as Marker of the Neural Health Profile in MED-EL CI Users: A Retrospective Analysis.Trends in hearingArticle
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Authors and funding
7 authors.
Funding
Abstract
Delayed loss of residual acoustic hearing after cochlear implantation is a common but poorly understood phenomenon due to the scarcity of relevant temporal bone tissues. Prior histopathological analysis of one case of post-implantation hearing loss suggested there were no interaural differences in hair cell or neural degeneration to explain the profound loss of low-frequency hearing on the implanted side (Quesnel et al., 2016) and attributed the threshold elevation to neo-ossification and fibrosis around the implant. Here we re-evaluated the histopathology in this case, applying immunostaining and improved microscopic techniques for differentiating surviving hair cells from supporting cells. The new analysis revealed dramatic interaural differences, with a > 80 % loss of inner hair cells in the cochlear apex on the implanted side, which can account for the post-implantation loss of residual hearing. Apical degeneration of the stria further contributed to threshold elevation on the implanted side. In contrast, spiral ganglion cell survival was reduced in the region of the electrode on the implanted side, but apical counts in the two ears were similar to that seen in age-matched unimplanted control ears. Almost none of the surviving auditory neurons retained peripheral axons throughout the basal half of the cochlea. Relevance to cochlear implant performance is discussed.
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