ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2024
Social Factors Associated With Congenital Syphilis in Missouri.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Associations Between Community Social Vulnerability or Socioeconomic Deprivation and Respiratory Virus Infection in Decedents in a Large, Urban Medical Examiner's Office.Journal of racial and ethnic health disparities · 2026Article
- Identifying missed prevention opportunities: maternal and congenital syphilis in hospital records and birth certificates in California from 2011 to 2021.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Patterns of Congenital Syphilis in a Large Public Hospital: Maternal Risk Factors and Infant Outcomes.Sexually transmitted diseases · 2025Article
- Multilevel Drivers of Congenital Syphilis, Oregon, 2013 to 2021.Sexually transmitted diseases · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundCongenital syphilis disproportionately affects individuals impacted by adverse social determinants of health. Understanding these determinants may help facilitate holistic care.
methodsWe performed a retrospective review of mother-infant dyads with potential congenital syphilis in a Missouri hospital system. Cases were classified per Centers for Disease Control and Prevention clinical scenarios. Information was collected regarding demographics, prenatal care, substance use, and other social factors. Dyads with confirmed/highly probable or possible congenital syphilis ("congenital syphilis outcomes") were compared to those with less likely/unlikely congenital syphilis ("noncongenital syphilis outcomes") using descriptive statistics.
resultsWe identified 131 dyads with infant dates of birth from 2015 to 2022: 74 (56%) with congenital syphilis outcomes and 56 (43%) with noncongenital syphilis outcomes. Most mothers were Black/African American (n = 84 [65%]) and lived in areas with a high Social Vulnerability Index. Many had inadequate prenatal care (n = 61 [47%]) and/or had substance use histories (n = 55 [42%]). Significant associations (odds ratio [95% confidence interval]) with congenital syphilis outcomes included limited prenatal care (3.01 [1.38-6.56]), no prenatal care (16.08 [1.96-132.11]), substance use (3.42 [1.61-7.25]), housing instability (3.42 [1.39-8.38]), and justice system interactions (2.29 [1.00-5.24]). Substance use correlated with prenatal care adequacy (P < .001). One-third of infants with congenital syphilis outcomes were taken into protective custody.
conclusionsAdverse social determinants of health are common in dyads impacted by congenital syphilis. Health systems should consider interdisciplinary programming to improve testing and linkage to care. Future studies should evaluate social support for congenital syphilis prevention and management.
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