Evidence map›Paper›PMID 38734792›Full record

ArticleMolecular biology reports2024

Gene expression of iron transporters, markers of vascularization and structural integrity in placenta of mothers with and without anemia.

Madhav Arora, Mohit Mehndiratta, Edelbert Anthonio Almeida, Mrinalini Kotru, Bindiya Gupta

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Madhav AroraUniversity College of Medical Sciences & GTB Hospital, University of Delhi, Delhi, India.ORCID http://orcid.org/0009-0006-6010-0355
Mohit MehndirattaDepartment of Biochemistry, University College of Medical Sciences & GTB Hospital, University of Delhi, Delhi, 110095, India. drmohitucms@gmail.com.ORCID http://orcid.org/0000-0002-0822-6544
Edelbert Anthonio AlmeidaDepartment of Biochemistry, University College of Medical Sciences & GTB Hospital, University of Delhi, Delhi, 110095, India.ORCID http://orcid.org/0000-0001-8301-7964
Mrinalini KotruDepartment of Pathology, University College of Medical Sciences and GTB Hospital, University of Delhi, Delhi, India.
Bindiya GuptaDepartment of Obstetrics and Gynaecology, University College of Medical Sciences & GTB Hospital, University of Delhi, Delhi, India.ORCID http://orcid.org/0000-0002-2555-9607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the mRNA expression of placental iron transporters (TfR-1 and FPN), markers of placental vascularization (VEGF and sFLT1) and marker of structural integrity (LMN-A) in term women with and without iron deficiency anemia. MATERIALS AND

methodsA total of 30 pregnant women were enrolled; 15 cases of iron deficiency anemia (Hb 7-10.9 gm/dL) and 15 gestational age matched healthy controls (Hb ≥ 11 gm/dL). Peripheral venous blood was collected for assessment of hemoglobin levels and serum iron profile. Placental tissue was used for assessing the mRNA expression of TfR-1, FPN, VEGF, sFLT-1 and LMN-A via real time PCR.

resultsPlacental expression of TfR-1, VEGF and LMN-A was increased in pregnant women with anemia compared to healthy pregnant controls. Placental expression of sFLT-1 was decreased in pregnant women with anemia compared to healthy pregnant controls. There was no change in the placental expression of FPN.

conclusionThe increased expression of TfR-1, VEGF and LMN-A in cases of iron deficiency anemia are most likely to be compensatory in nature to help maintain adequate fetal iron delivery. WHAT DOES THIS STUDY ADDS TO THE CLINICAL WORK: Compensatory changes in the placenta aimed at buffering transport of iron to the fetus are seen in pregnant women with anemia compared to healthy pregnant controls.

Indexed as

Anemia, Iron-DeficiencyBiomarkersCation Transport ProteinsIronPlacentaReceptors, TransferrinVascular Endothelial Growth Factor AAdultAntigens, CDCase-Control StudiesFemaleFerroportinGene ExpressionHumansPregnancyRNA, MessengerAntigens, CDBiomarkersCation Transport ProteinsCD71 antigenFerroportinFLT1 protein, humanIronReceptors, TransferrinRNA, MessengerVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1VEGFA protein, humanAnemia in pregnancyAngiogenesis-antiangiogenesisIron transportLMN-APlacental hemodynamics

Identifiers

PMID38734792

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