ArticleNature communications2024
The greenbeard gene tgrB1 regulates altruism and cheating in Dictyostelium discoideum.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Aggregative chimeric multicellularity in the absence of lethal kin discrimination.The ISME journal · 2026Article
- Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mutual suppression between mutations in the Dictyostelium Greenbeard pathway restores wild-type development.BMC genomics · 2025Article
- Identification of regions required for allelic specificity at the cell wall remodeling allorecognition checkpoint in Neurospora crassa.Genetics · 2025Article
- Testing the coordination hypothesis: incompatibilities in aggregative development of an experimentally evolved social amoeba.Evolution letters · 2025Article
- Going against the family: Perturbation of a greenbeard pathway leads to falsebeard cheating.iScience · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Greenbeard genetic elements encode rare perceptible signals, signal recognition ability, and altruism towards others that display the same signal. Putative greenbeards have been described in various organisms but direct evidence for all the properties in one system is scarce. The tgrB1-tgrC1 allorecognition system of Dictyostelium discoideum encodes two polymorphic membrane proteins which protect cells from chimerism-associated perils. During development, TgrC1 functions as a ligand-signal and TgrB1 as its receptor, but evidence for altruism has been indirect. Here, we show that mixing wild-type and activated tgrB1 cells increases wild-type spore production and relegates the mutants to the altruistic stalk, whereas mixing wild-type and tgrB1-null cells increases mutant spore production and wild-type stalk production. The tgrB1-null cells cheat only on partners that carry the same tgrC1-allotype. Therefore, TgrB1 activation confers altruism whereas TgrB1 inactivation causes allotype-specific cheating, supporting the greenbeard concept and providing insight into the relationship between allorecognition, altruism, and exploitation.
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