Evidence map›Paper›PMID 38734716›Full record

ArticleScientific reports2024

Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies.

Pinja Tissarinen, Heli Tiensuu, Antti M Haapalainen, Eveliina Ronkainen, Liisa Laatio, Marja Vääräsmäki, Hanna Öhman, Mikko Hallman, Mika Rämet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pinja TissarinenResearch Unit of Clinical Medicine and Medical Research Center, Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, University of Oulu, PO Box 5000, 90014, Oulu, Finland.
Heli TiensuuResearch Unit of Clinical Medicine and Medical Research Center, Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, University of Oulu, PO Box 5000, 90014, Oulu, Finland.
Antti M HaapalainenResearch Unit of Clinical Medicine and Medical Research Center, Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, University of Oulu, PO Box 5000, 90014, Oulu, Finland.
Eveliina RonkainenResearch Unit of Clinical Medicine and Medical Research Center, Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, University of Oulu, PO Box 5000, 90014, Oulu, Finland.
Liisa LaatioResearch Unit of Clinical Medicine, Department of Obstetrics and Gynecology, Oulu University Hospital, University of Oulu, Oulu, Finland.
Marja VääräsmäkiResearch Unit of Clinical Medicine and Medical Research Center, Department of Obstetrics and Gynecology, Oulu University Hospital, University of Oulu, Oulu, Finland.
Hanna ÖhmanFaculty of Medicine, Biobank Borealis of Northern Finland, Oulu University Hospital, University of Oulu, Oulu, Finland.
Mikko Hallman *Research Unit of Clinical Medicine and Medical Research Center, Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, University of Oulu, PO Box 5000, 90014, Oulu, Finland. mikko.hallman@oulu.fi.
Mika Rämet *Research Unit of Clinical Medicine and Medical Research Center, Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, University of Oulu, PO Box 5000, 90014, Oulu, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, there are no accurate means to predict spontaneous preterm birth (SPTB). Recently, we observed low expression of alpha-1 antitrypsin (AAT) in SPTB placentas. Present aim was to compare the concentrations of maternal serum AAT in pregnancies with preterm and term deliveries. Serum C-reactive protein (CRP) was used as a reference inflammatory marker. Two populations were studied. The first population comprised women who eventually gave birth spontaneously preterm (SPTB group) or term (control group). The second population included pregnant women shortly before delivery and nonpregnant women. We observed that serum AAT levels were higher in the SPTB group than in the controls, and a similar difference was observed when serum CRP was considered in multivariable analysis. However, the overlap in the AAT concentrations was considerable. No statistical significance was observed in serum AAT levels between preterm and term pregnancies at delivery. However, AAT levels were higher at delivery compared to nonpregnant controls. We did not observe a strong correlation between serum AAT and CRP in early pregnancy samples and at labor. We propose that during early pregnancy, complicated by subsequent SPTB, modest elevation of serum AAT associates with SPTB.

Indexed as

alpha 1-AntitrypsinC-Reactive ProteinPremature BirthAdultBiomarkersCase-Control StudiesFemaleHumansInfant, NewbornPregnancyTerm Birthalpha 1-AntitrypsinBiomarkersC-Reactive ProteinSERPINA1 protein, human

Identifiers

PMID38734716
PMCPMC11088650

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.