ArticleNature communications2024
Cerebellar Purkinje cells in male macaques combine sensory and motor information to predict the sensory consequences of active self-motion.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Learning Gravity: An Innately Constrained Bayesian Model of Human Vestibular Development.Audiology research · 2026Article
- Virtual reality stimulation modulates saccular activity and vestibular system responses.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells.Journal of neurophysiology · 2026Review
- Ground-truth encoding of self-motion in the primate cerebellar nodulus and uvula.Nature communications · 2026Article
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- Suppressing Sensation during Action across Species and Sensory Modalities: Predictive and Nonpredictive Mechanisms of Sensory Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Multisensory coding of self-motion and its contribution to navigation.Nature reviews. Neuroscience · 2025Review
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- Sensorimotor Transformations for Postural Control in the Vermis of the Cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Validating sensory conflict theory and mitigating motion sickness in humans with galvanic vestibular stimulation.Communications engineering · 2025Article
- Predictive reward-prediction errors of climbing fiber inputs integrate modular reinforcement learning with supervised learning.PLoS computational biology · 2025Article
- Convergence of vestibular and proprioceptive signals in the cerebellar nodulus/uvula enhances the encoding of self-motion in primates.Current biology : CB · 2025Article
- Potential therapeutic effects of Ebixa,Frontiers in neuroscience · 2025Article
- Commissural and monosynaptic inputs to medial vestibular nucleus GABAergic neurons in mice.Frontiers in neurology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Accurate perception and behavior rely on distinguishing sensory signals arising from unexpected events from those originating from our own voluntary actions. In the vestibular system, sensory input that is the consequence of active self-motion is canceled early at the first central stage of processing to ensure postural and perceptual stability. However, the source of the required cancellation signal was unknown. Here, we show that the cerebellum combines sensory and motor-related information to predict the sensory consequences of active self-motion. Recordings during attempted but unrealized head movements in two male rhesus monkeys, revealed that the motor-related signals encoded by anterior vermis Purkinje cells explain their altered sensitivity to active versus passive self-motion. Further, a model combining responses from ~40 Purkinje cells accounted for the cancellation observed in early vestibular pathways. These findings establish how cerebellar Purkinje cells predict sensory outcomes of self-movements, resolving a long-standing issue of sensory signal suppression during self-motion.
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