Evidence map›Paper›PMID 38734312›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2024

A novel microporous biomaterial vaccine platform for long-lasting antibody mediated immunity against viral infection.

Daniel P Mayer, Mariah E Nelson, Daria Andriyanova, Renata B Filler, Arya Ökten, Olivia Q Antao, Jennifer S Chen, Philip O Scumpia, Westbrook M Weaver, Craig B Wilen and 2 more

Abstract read
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Daniel P MayerCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, United States of America.
Mariah E NelsonTempo Therapeutics, 3030 Bunker Hill st., suite 104, San Diego, CA 92109, United States of America.
Daria AndriyanovaTempo Therapeutics, 3030 Bunker Hill st., suite 104, San Diego, CA 92109, United States of America.
Renata B FillerDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06510, United States of America.
Arya ÖktenDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06510, United States of America; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, United States of America.
Olivia Q AntaoCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, United States of America.
Jennifer S ChenDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06510, United States of America; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, United States of America.
Philip O ScumpiaDepartment of Medicine, Division of Dermatology, University of California Los Angeles, Los Angeles, California, United States of America; Department of Dermatology, West Los Angeles Veteran Affairs Medical Center, Los Angeles, California, United States of America.
Westbrook M WeaverTempo Therapeutics, 3030 Bunker Hill st., suite 104, San Diego, CA 92109, United States of America.
Craig B WilenDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06510, United States of America; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, United States of America.
Stephanie DeshayesTempo Therapeutics, 3030 Bunker Hill st., suite 104, San Diego, CA 92109, United States of America.
Jason S WeinsteinCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, United States of America. Electronic address: jason.weinstein@rutgers.edu.

Funding

Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHARPEE, TATYANA O. · 2020 to 2024
$6.0M
T cell regulation of pathogenic B cells in systemic autoimmunityR01AR073912 · NIAMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Jason Weinstein · 2018 to 2026
$3.2M
Regulation of T cell-derived cytokines in allergic airway inflammationF30HL149151 · NHLBI · YALE UNIVERSITY · PI CHEN, JENNIFER S · 2020 to 2022
$113k
NHLBI NIH HHS F30 HL149151NIAMS NIH HHS R01 AR073912NIA NIH HHS P30 AG068635NIGMS NIH HHS T32 GM136651
6 · The paper itself

Abstract

Current antigen delivery platforms, such as alum and nanoparticles, are not readily tunable, thus may not generate optimal adaptive immune responses. We created an antigen delivery platform by loading lyophilized Microporous Annealed Particle (MAP) with aqueous solution containing target antigens. Upon administration of antigen loaded MAP (VaxMAP), the biomaterial reconstitution forms an instant antigen-loaded porous scaffold area with a sustained release profile to maximize humoral immunity. VaxMAP induced CD4

Indexed as

COVID-19COVID-19 VaccinesImmunity, HumoralSpike Glycoprotein, CoronavirusAnimalsAntibodies, NeutralizingAntibodies, ViralBiocompatible MaterialsB-LymphocytesFemaleInfluenza VaccinesMiceMice, Inbred BALB CMice, Inbred C57BLOrthomyxoviridae InfectionsPorosityAntibodies, NeutralizingAntibodies, ViralBiocompatible MaterialsCOVID-19 VaccinesInfluenza VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Antigen delivery platformBiomaterialSustained releaseVaccine platform

Identifiers

PMID38734312
PMCPMC11665867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.