Evidence map›Paper›PMID 38734032›Full record

ArticleJornal de pediatria

Inflammatory markers in prepubertal children and their associations with abdominal fat.

Letícia G de Queiroz, Paulo F Collett-Solberg, Maria das Graças C de Souza, Nádia Cristina P Rodrigues, Alexandra M Monteiro, Cristiane de S Mendes, Fernanda M Gazolla, Cecília L de Oliveira, Eliete Bouskela, Maria Cristina C Kuschnir and 1 more

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Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Letícia G de QueirozUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Programa de Pós-Graduação em Ciências Médicas, Rio de Janeiro, RJ, Brazil. Electronic address: leticiagqueiroz@gmail.com.
Paulo F Collett-SolbergUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Medicina Interna, Disciplina de Endocrinologia, Rio de Janeiro, RJ, Brazil.
Maria das Graças C de SouzaUniversidade do Estado do Rio de Janeiro, Centro Biomédico, Laboratório de Pesquisas Clínicas e Experimentais em Biologia Vascular, Rio de Janeiro, RJ, Brazil.
Nádia Cristina P RodriguesUniversidade do Estado do Rio de Janeiro, Instituto de Medicina Social Hésio Cordeiro, Rio de Janeiro, RJ, Brazil.
Alexandra M MonteiroUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Rio de Janeiro, RJ, Brazil.
Cristiane de S MendesUniversidade do Estado do Rio de Janeiro, Hospital Universitário Pedro Ernesto, Laboratório de Hormônios, Rio de Janeiro, RJ, Brazil.
Fernanda M GazollaUniversidade do Estado do Rio de Janeiro, Hospital Universitário Pedro Ernesto, Unidade de Ensino de Endocrinologia e Metabologia, Rio de Janeiro, RJ, Brazil.
Cecília L de OliveiraUniversidade do Estado do Rio de Janeiro, Instituto de Nutrição, Departamento de Nutrição Aplicada, Rio de Janeiro, RJ, Brazil.
Eliete BouskelaUniversidade do Estado do Rio de Janeiro, Centro Biomédico, Laboratório de Pesquisas Clínicas e Experimentais em Biologia Vascular, Rio de Janeiro, RJ, Brazil.
Maria Cristina C KuschnirUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Pediatria, Rio de Janeiro, RJ, Brazil.
Isabel R MadeiraUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Pediatria, Rio de Janeiro, RJ, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the association between inflammatory markers and abdominal fat assessed by ultrasound in prepubertal children with and without excess weight.

methodsA cross-sectional study involving 241 prepubertal children, 156 with obesity, 37 with overweight, and 48 with normal weight, aged five to ten years, who were followed at a research unit on Childhood Obesity from a teaching hospital belonging to a public health system. The concentration of interleukin-6, tumor necrosis factor-α and C-reactive protein were assessed and regression analyses, considering outcome variables such as abdominal wall and intra-abdominal fat thickness measured by ultrasound, were performed.

resultsThe findings highlighted an association between abdominal fat and inflammatory markers, even in children at this young age group. Subcutaneous fat showed a stronger association with inflammatory biomarkers compared to intra-abdominal fat when performing logistic regression, with a positive association between tumor necrosis factor-α and abdominal wall thickness equal to or greater than the 75th percentile in adjusted logistic regression (OR: 18.12; CI 95 %: 1.57: 209.55).

conclusionsAbdominal wall fat, in contrast to what is often observed in adults, appears to have a greater impact on chronic inflammation related to excessive weight in very young children.

Indexed as

Abdominal FatBiomarkersC-Reactive ProteinInterleukin-6Tumor Necrosis Factor-alphaUltrasonographyBody Mass IndexChildChild, PreschoolCross-Sectional StudiesFemaleHumansInflammationIntra-Abdominal FatMaleOverweightBiomarkersC-Reactive ProteinInterleukin-6Tumor Necrosis Factor-alphaAbdominal fatInflammationPediatric obesity

Identifiers

PMID38734032
PMCPMC11361872

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.